GTPase-Activating Proteins

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  Subject Areas on Research

  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. 
  • A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. 
  • A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. 
  • A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. 
  • ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. 
  • ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. 
  • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. 
  • Beyond symmetry-breaking: competition and negative feedback in GTPase regulation. 
  • Bi-modal regulation of a formin by srGAP2. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. 
  • Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring. 
  • Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. 
  • Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions. 
  • Consensus nomenclature for the human ArfGAP domain-containing proteins. 
  • Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. 
  • Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia. 
  • Differences between AGAP1, ASAP1 and Arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1. 
  • Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes. 
  • Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk. 
  • GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. 
  • GIT1 regulates synaptic structural plasticity underlying learning. 
  • GIT2-A keystone in ageing and age-related disease. 
  • GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. 
  • Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. 
  • Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. 
  • Genome-wide association study of sepsis in extremely premature infants. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. 
  • Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. 
  • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. 
  • Id proteins synchronize stemness and anchorage to the niche of neural stem cells. 
  • Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. 
  • Impaired fear response in mice lacking GIT1. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Inhibition of Cdc42 during mitotic exit is required for cytokinesis. 
  • Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. 
  • LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. 
  • Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy. 
  • Mammalian Scribble forms a tight complex with the betaPIX exchange factor. 
  • Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. 
  • Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. 
  • Nuclear GIT2 is an ATM substrate and promotes DNA repair. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. 
  • Purification and characterization of GIT family of ADP-ribosylation factor (ARF) GTPase-activating proteins. 
  • RALA and RALBP1 regulate mitochondrial fission at mitosis. 
  • RAP2 mediates mechanoresponses of the Hippo pathway. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Ras, superoxide and signal transduction. 
  • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. 
  • SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. 
  • Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. 
  • Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. 
  • Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. 
  • Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist. 
  • TSC2: filling the GAP in the mTOR signaling pathway. 
  • The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. 
  • The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. 
  • The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint. 
  • The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. 
  • Transethnic genome-wide scan identifies novel Alzheimer's disease loci. 
  • Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology