GTPase-Activating Proteins
-
Subject Areas on Research
-
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
-
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.
-
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
-
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
-
ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
-
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
-
Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition.
-
Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.
-
An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.
-
Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.
-
Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes.
-
Anxiety-like behaviors in mice lacking GIT2.
-
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
-
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
-
Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.
-
Bi-modal regulation of a formin by srGAP2.
-
Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
-
COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.
-
CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.
-
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.
-
Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring.
-
Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
-
Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms.
-
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
-
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
-
Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.
-
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
-
Discovery and characterization of small molecules that target the GTPase Ral.
-
Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes.
-
Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk.
-
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6.
-
GIT1 regulates synaptic structural plasticity underlying learning.
-
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
-
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
-
Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.
-
Genome-wide association study of sepsis in extremely premature infants.
-
Genomic organization and cloning of the human homologue of murine Sipa-1.
-
High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.
-
Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.
-
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.
-
Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
-
Id proteins synchronize stemness and anchorage to the niche of neural stem cells.
-
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
-
Impaired fear response in mice lacking GIT1.
-
In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
-
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
-
Inhibition of Cdc42 during mitotic exit is required for cytokinesis.
-
Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.
-
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
-
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
-
Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging.
-
Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.
-
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
-
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
-
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
-
RAP2 mediates mechanoresponses of the Hippo pathway.
-
RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
-
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development.
-
Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada.
-
Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
-
Regulation of Rac1 translocation and activation by membrane domains and their boundaries.
-
Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels.
-
Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
-
SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.
-
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
-
Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.
-
Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.
-
Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level.
-
TSC2: filling the GAP in the mTOR signaling pathway.
-
The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
-
The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.
-
The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
-
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
-
The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint.
-
The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9.
-
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
-
The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
-
The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
-
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.
-
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
-
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
-
Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
-
Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection.
-
WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.
-
Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
-
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
-
Keywords of People
-
Bejsovec, Amy,
Associate Professor of Biology,
Biology
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Lew, Daniel Julio,
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology,
Cell Biology
-
Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology