rab GTP-Binding Proteins

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  Subject Areas on Research

  • A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity. 
  • A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • CHML promotes liver cancer metastasis by facilitating Rab14 recycle. 
  • Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. 
  • Clinical and functional findings in choroideremia due to complete deletion of the CHM gene. 
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. 
  • Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. 
  • Congenital hemophagocytic lymphohistiocytosis presenting as thrombocytopenia in a newborn. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization. 
  • Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. 
  • Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. 
  • Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain. 
  • Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. 
  • Interaction between bud-site selection and polarity-establishment machineries in budding yeast. 
  • Isoprenylcysteine carboxyl methyltransferase deficiency in mice. 
  • LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. 
  • LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. 
  • Large-scale profiling of Rab GTPase trafficking networks: the membrome. 
  • Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. 
  • Molecular characterization of CLPT1, a SEC4-like Rab/GTPase of the phytopathogenic fungus Colletotrichum lindemuthianum which is regulated by the carbon source. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. 
  • The secretory pathway in control of endoplasmic reticulum homeostasis. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. 
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  Keywords of People

  • West, Andrew Bradley, Professor of Pharmacology and Cancer Biology, Cell Biology