ras GTPase-Activating Proteins
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Subject Areas on Research
- A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
- An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
- Cell surface polarization during yeast mating.
- Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
- Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.
- Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
- IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
- Inhibition of Cdc42 during mitotic exit is required for cytokinesis.
- Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
- Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
- RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
- Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels.
- SENP3-mediated host defense response contains HBV replication and restores protein synthesis.
- Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
- The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
- The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.