RGS Proteins

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  Subject Areas on Research

  • A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. 
  • Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 
  • Activation of transducin guanosine triphosphatase by two proteins of the RGS family. 
  • Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. 
  • Biology and functions of the RGS9 isoforms. 
  • Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. 
  • Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. 
  • Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. 
  • Functional comparison of RGS9 splice isoforms in a living cell. 
  • G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. 
  • GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. 
  • Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. 
  • Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo. 
  • Genome sequencing unveils a regulatory landscape of platelet reactivity. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Kinetic approaches to study the function of RGS9 isoforms. 
  • Kinetic mechanism of RGS9-1 potentiation by R9AP. 
  • Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins. 
  • Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 
  • Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. 
  • Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. 
  • Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer. 
  • Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. 
  • RGS expression rate-limits recovery of rod photoresponses. 
  • RGS10 is a selective activator of G alpha i GTPase activity. 
  • RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival. 
  • RGS2: a "turn-off" in hypertension. 
  • RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. 
  • RGS9 knockout causes a short delay in light responses of ON-bipolar cells. 
  • RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. 
  • Regulator of G-protein signaling (RGS) proteins in cancer biology. 
  • Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. 
  • Regulator of G-protein signalling expression and function in ovarian cancer cell lines. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. 
  • Renal actions of RGS2 control blood pressure. 
  • Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. 
  • Specificity of G protein-RGS protein recognition is regulated by affinity adapters. 
  • The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. 
  • The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. 
  • The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling. 
  • Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. 
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  Keywords of People

  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology