ral GTP-Binding Proteins

• 

  Subject Areas on Research

  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.