Leptin

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  Subject Areas on Research

  • A controlled high-fat diet induces an obese syndrome in rats. 
  • A link between leptin and steatosis in chronic hepatitis C? Time to weigh up the fats. 
  • A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding. 
  • Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. 
  • Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity. 
  • Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. 
  • Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. 
  • Animal models of steatohepatitis. 
  • Animal models of steatosis. 
  • Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. 
  • Are epigenetic changes in the intrauterine environment related to newborn neurobehavior? 
  • Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment. 
  • Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis. 
  • Body composition and mortality after adult lung transplantation in the United States. 
  • Body weight and fat deposition in prolactin receptor-deficient mice. 
  • Bone density and amenorrhea in ballet dancers are related to a decreased resting metabolic rate and lower leptin levels. 
  • C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Cardiometabolic Health in Submariners Returning from a 3-Month Patrol. 
  • Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting. 
  • Changes in serum leptin levels as well as sICAM-1 and sVCAM-1 soluble adhesion molecules during carotid endarterectomy. 
  • Chondroprotection of leptin deficiency demystified? 
  • Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. 
  • Circulating Leptin and Branched Chain Amino Acids-Correlation with Intraductal Papillary Mucinous Neoplasm Dysplastic Grade. 
  • Cloned mice have an obese phenotype not transmitted to their offspring. 
  • Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia. 
  • Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. 
  • DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function. 
  • Determinants of increased energy expenditure in HIV-infected women. 
  • Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. 
  • Diet-induced obese mice retain endogenous leptin action. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. 
  • Direct antidiabetic effect of leptin through triglyceride depletion of tissues. 
  • Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. 
  • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 
  • Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. 
  • Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. 
  • Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition. 
  • Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma. 
  • Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. 
  • Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in Asian adults. 
  • Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. 
  • Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. 
  • Evidence for metabolic and endocrine abnormalities in subjects recovered from anorexia nervosa. 
  • Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans. 
  • Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. 
  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. 
  • Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal. 
  • Ghrelin and hypothalamic development: too little and too much of a good thing. 
  • Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. 
  • Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. 
  • Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage. 
  • Hungry irony. 
  • Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. 
  • Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. 
  • Increased leptin levels correlate with thyroid autoantibodies in nonobese males. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. 
  • Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood. 
  • Leptin and ghrelin in relation to Helicobacter pylori status in adult males. 
  • Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. 
  • Leptin as a Predictor of Incident Asthma in Offspring of Obese Mothers. 
  • Leptin directly alters lipid partitioning in skeletal muscle. 
  • Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. 
  • Leptin in the newborn mouse. Plasma concentrations, characterization of the circulating hormone, and tissue source. 
  • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. 
  • Leptin levels and luteinizing hormone pulsatility in normal cycling women and their relationship to daily changes in metabolic rate. 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. 
  • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. 
  • Leptin regulates proinflammatory immune responses. 
  • Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. 
  • Leptin therapy in insulin-deficient type I diabetes. 
  • Leveraging leptin for type I diabetes? 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. 
  • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects. 
  • Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy. 
  • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. 
  • Melatonin regulates energy balance and attenuates fever in Siberian hamsters. 
  • Metabolic effects of dietary lactose in adult female rats. 
  • Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone. 
  • Metabolomics in nutrition research: biomarkers predicting mortality in children with severe acute malnutrition. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma. 
  • Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. 
  • Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. 
  • Neural and hormonal regulation of pancreatic secretion. 
  • Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. 
  • Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. 
  • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. 
  • Nutritional effects on T-cell immunometabolism. 
  • OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. 
  • Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study. 
  • Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • Pediatric narcolepsy. 
  • Peripheral metabolic actions of leptin. 
  • Peritumoral expression of adipokines and fatty acids in breast cancer. 
  • Pharmacologic manipulation of ob expression in a dietary model of obesity. 
  • Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. 
  • Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity. 
  • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. 
  • Physiology of weight loss surgery. 
  • Placental hormones and the control of maternal metabolism and fetal growth. 
  • Plasma leptin levels and coronary artery calcification in older adults. 
  • Presence of leptin in breast cell lines and breast tumors. 
  • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. 
  • Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. 
  • Recent advances in pancreatic endocrine and exocrine secretion. 
  • Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Revisiting lessons from the C57BL/6J mouse. 
  • Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. 
  • Role of leptin in fat regulation. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Screening for hormonal, monogenic, and syndromic disorders in obese infants and children. 
  • Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy. 
  • Serum leptin and age-related macular degeneration. 
  • Serum leptin levels are inversely correlated with omental gene expression of adiponectin and markedly decreased after gastric bypass surgery. 
  • Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis. 
  • Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition. 
  • Sympathetic nervous system regulation of liver repair. 
  • The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. 
  • The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. 
  • The association of gastric leptin with oesophageal inflammation and metaplasia. 
  • The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. 
  • The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. 
  • The effects of adipokines on cartilage and meniscus catabolism. 
  • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. 
  • The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index. 
  • The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity. 
  • Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice. 
  • Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. 
  • beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics