rho GTP-Binding Proteins

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  Subject Areas on Research

  • ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. 
  • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Analysis of Rho-GTPase Activity During Budding Yeast Cytokinesis. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Cell adhesion: separation of p120's powers? 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases 
  • Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. 
  • Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. 
  • Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. 
  • Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains. 
  • Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort. 
  • Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. 
  • Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Morphogenesis: multitalented GTPases seeking new jobs. 
  • Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis. 
  • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. 
  • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Phosphorylation-dependent control of ZIPK nuclear import is species specific. 
  • Principles that govern competition or co-existence in Rho-GTPase driven polarization. 
  • RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. 
  • Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. 
  • STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. 
  • Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. 
  • The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. 
  • The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. 
  • The pulling, pushing and fusing of lens fibers: a role for Rho GTPases. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • The type III TGFbeta receptor regulates directional migration: new tricks for an old dog. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics