Calcium Channels, L-Type

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  Subject Areas on Research

  • A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. 
  • Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II. 
  • Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. 
  • Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. 
  • Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. 
  • Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. 
  • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. 
  • Calcineurin finds a new partner in the L-type Ca2+ channel. 
  • Calcium Channel Mutations in Cardiac Arrhythmia Syndromes. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. 
  • Calmodulin and CaMKII as molecular switches for cardiac ion channels. 
  • Calmodulin mediates Ca2+ sensitivity of sodium channels. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • De novo CACNA1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism. 
  • Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Excitation-contraction coupling in airway smooth muscle. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins. 
  • Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Mouse model of Timothy syndrome recapitulates triad of autistic traits. 
  • Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current. 
  • Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. 
  • Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation. 
  • Proteolytic cleavage and PKA phosphorylation of α_1C subunit are not required for adrenergic regulation of Ca_V 1.2 in the heart. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. 
  • STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. 
  • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 
  • Signal transduction. Bringing channels closer to the action! 
  • Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. 
  • T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle. 
  • The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear. 
  • The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • The real estate of cardiac signaling: location, location, location. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology