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Subject Areas on Research
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A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis.
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A method to measure myocardial calcium handling in adult Drosophila.
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Accessory subunit KChIP2 modulates the cardiac L-type calcium current.
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Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
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Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.
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Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
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Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.
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BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.
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Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.
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Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.
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Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.
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CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
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Calcineurin finds a new partner in the L-type Ca2+ channel.
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Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.
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Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
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Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.
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Calmodulin and CaMKII as molecular switches for cardiac ion channels.
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Calmodulin mediates Ca2+ sensitivity of sodium channels.
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Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
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Calmodulin supports both inactivation and facilitation of L-type calcium channels.
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Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.
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Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers.
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Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments.
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Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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De novo CACNA1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism.
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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
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Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
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Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Excitation-contraction coupling in airway smooth muscle.
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Fibroblast growth factor homologous factors modulate cardiac calcium channels.
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Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
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Genome-wide association study of bipolar I disorder in the Han Chinese population.
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High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle.
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Hypoxia reprograms calcium signaling and regulates myoglobin expression.
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Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
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Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
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Is otilonium bromide globally effective in irritable bowel syndrome?
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Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
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L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
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Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels.
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Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels.
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Mouse model of Timothy syndrome recapitulates triad of autistic traits.
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Neural crest and cardiovascular development: a 20-year perspective.
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Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current.
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Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts.
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Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations.
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Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.
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Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.
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Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells.
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Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission.
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Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.
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STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
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Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
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Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
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Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells.
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T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle.
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The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.
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The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
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The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.
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The real estate of cardiac signaling: location, location, location.
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Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.
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p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes.
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Keywords of People