Matrix Metalloproteinase 9

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  Subject Areas on Research

  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Angiostatin directly inhibits human prostate tumor cell invasion by blocking plasminogen binding to its cellular receptor, CD26. 
  • Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury. 
  • Biology of cerebral arteriovenous malformations with a focus on inflammation. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery. 
  • Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. 
  • Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study. 
  • Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice. 
  • Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. 
  • Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection. 
  • Discriminative capacity of biomarkers for acute stroke in the emergency department. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. 
  • Doxycycline alters collagen composition following ventral hernia repair. 
  • Doxycycline shows dose-dependent changes in hernia repair strength after mesh repair. 
  • Early biomarkers of stroke. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions. 
  • Effects of titanium particle size on osteoblast functions in vitro and in vivo. 
  • Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer. 
  • Epiregulin and EGFR interactions are involved in pain processing. 
  • Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model. 
  • Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer. 
  • Functional selection of protease inhibitory antibodies. 
  • Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. 
  • HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase. 
  • IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. 
  • Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. 
  • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. 
  • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. 
  • Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells. 
  • Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. 
  • Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing. 
  • Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. 
  • Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure. 
  • Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome. 
  • Matrix metalloprotease regulation of neuropathic pain. 
  • Matrix metalloproteinase 9 positivity predicts long term decreased tear production. 
  • Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse. 
  • Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. 
  • Mechanisms of action of rapamycin in gliomas. 
  • Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature. 
  • Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells. 
  • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. 
  • Nicotine increases size and severity of experimental choroidal neovascularization. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. 
  • Novel diagnostic test for acute stroke. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy. 
  • Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction. 
  • Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. 
  • Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro. 
  • Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells. 
  • Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population. 
  • RGS-GAIP-interacting protein controls breast cancer progression. 
  • Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis. 
  • Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades. 
  • Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. 
  • Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation. 
  • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. 
  • Serum Calprotectin as a Novel Biomarker in Abdominal Aortic Aneurysm Pathogenesis and Progression: Preliminary Data from Experimental Model in Rats. 
  • Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. 
  • Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. 
  • Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma. 
  • Structural remodelling in heart failure: gelatinase induction. 
  • Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair. 
  • Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. 
  • TGF-beta: a new role for an old AktTOR. 
  • TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation. 
  • The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro. 
  • The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye. 
  • The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection. 
  • The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells. 
  • Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. 
  • Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds 
  • Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer. 
  • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. 
  • Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. 
  • Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.