Matrix Metalloproteinases
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Subject Areas on Research
- A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.
- Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity.
- Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.
- Airway fibroblasts in asthma manifest an invasive phenotype.
- Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling.
- Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.
- Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels.
- DNA delivery from matrix metalloproteinase degradable poly (ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells
- Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.
- Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
- Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.
- Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.
- ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
- Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy.
- Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
- Host-Directed Therapies for Tuberculosis.
- In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity.
- Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.
- Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures.
- Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture.
- Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro.
- Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
- Integrative repair of the meniscus: lessons from in vitro studies.
- Invasion and MMP expression profile in desmoid tumours.
- Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease.
- Matrix Metalloproteinases and Glaucoma Treatment.
- Matrix metalloprotease regulation of neuropathic pain.
- Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.
- Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
- Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization.
- Mechanisms of ATP release, the enabling step in purinergic dynamics.
- Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy.
- Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.
- Polarized monocyte response to cytokine stimulation.
- Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration.
- Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells.
- Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.
- Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18.
- Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2.
- SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.
- Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.
- Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.
- The effects of adipokines on cartilage and meniscus catabolism.
- The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
- The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels
- The tetraspanin superfamily member NET-6 is a new tumor suppressor gene.
- Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.
- Traversing the basement membrane in vivo: a diversity of strategies.
- Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.
- Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
- VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.