Matrix Metalloproteinases

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  Subject Areas on Research

  • A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis. 
  • Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity. 
  • Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. 
  • Airway fibroblasts in asthma manifest an invasive phenotype. 
  • Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling. 
  • An MMP-degraded and cross-linked fragment of type III collagen as a non-invasive biomarker of hepatic fibrosis resolution. 
  • Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model. 
  • DNA delivery from matrix metalloproteinase degradable poly (ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1. 
  • Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy. 
  • Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Host-Directed Therapies for Tuberculosis. 
  • In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity. 
  • Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture. 
  • Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures. 
  • Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture. 
  • Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro. 
  • Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Integrative repair of the meniscus: lessons from in vitro studies. 
  • Invasion and MMP expression profile in desmoid tumours. 
  • Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease. 
  • Matrix Metalloproteinases and Glaucoma Treatment. 
  • Matrix metalloprotease regulation of neuropathic pain. 
  • Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients. 
  • Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. 
  • Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. 
  • Mechanisms of ATP release, the enabling step in purinergic dynamics. 
  • Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium. 
  • Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy. 
  • Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease. 
  • Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure. 
  • Polarized monocyte response to cytokine stimulation. 
  • Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population. 
  • Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18. 
  • Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. 
  • Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. 
  • SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. 
  • Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. 
  • Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. 
  • Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. 
  • Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. 
  • The effects of adipokines on cartilage and meniscus catabolism. 
  • The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. 
  • The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels 
  • The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. 
  • The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer. 
  • Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture. 
  • Traversing the basement membrane in vivo: a diversity of strategies. 
  • Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. 
  • Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.