Matrix Metalloproteinases
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Subject Areas on Research
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A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.
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Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity.
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Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.
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Airway fibroblasts in asthma manifest an invasive phenotype.
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Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling.
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An MMP-degraded and cross-linked fragment of type III collagen as a non-invasive biomarker of hepatic fibrosis resolution.
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Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.
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Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels.
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Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.
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DNA delivery from matrix metalloproteinase degradable poly (ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells
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Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.
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Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
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Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.
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Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.
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Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy.
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Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D.
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Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
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Host-Directed Therapies for Tuberculosis.
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In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity.
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Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.
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Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures.
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Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture.
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Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro.
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Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition.
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Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
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Integrative repair of the meniscus: lessons from in vitro studies.
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Invasion and MMP expression profile in desmoid tumours.
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Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease.
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Matrix Metalloproteinases and Glaucoma Treatment.
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Matrix metalloprotease regulation of neuropathic pain.
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Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.
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Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
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Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization.
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Mechanisms of ATP release, the enabling step in purinergic dynamics.
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Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium.
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Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy.
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Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.
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Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure.
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Polarized monocyte response to cytokine stimulation.
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Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration.
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Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells.
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Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.
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Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18.
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Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling.
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Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2.
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SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.
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Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.
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Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.
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Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.
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Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
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The effects of adipokines on cartilage and meniscus catabolism.
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The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
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The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels
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The tetraspanin superfamily member NET-6 is a new tumor suppressor gene.
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The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
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Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.
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Traversing the basement membrane in vivo: a diversity of strategies.
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Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.
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Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
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VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.