Hemangioma, Cavernous, Central Nervous System
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Subject Areas on Research
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
- Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
- B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models.
- Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.
- Brainstem melanomas presenting as a cavernous malformation.
- Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.
- Cerebral Cavernous Malformation: From Mechanism to Therapy.
- Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells.
- Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
- Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas.
- Deletions in CCM2 are a common cause of cerebral cavernous malformations.
- Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
- Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
- Genetic genealogy uncovers a founder deletion mutation in the cerebral cavernous malformations 2 gene.
- Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.
- Impact of signal-to-noise on functional MRI.
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
- Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.
- Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
- Neuro-oculo-cutaneous cavernous hemangiomas: a CCM1 mutation-associated phakomatosis.
- Novel Murine Models of Cerebral Cavernous Malformations.
- PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
- Phenotypic characterization of murine models of cerebral cavernous malformations.
- Preoperative evaluation of neural tracts by use of three-dimensional anisotropy contrast imaging in a patient with brainstem cavernous angioma: technical case report.
- Prolonged Cardiac Dysfunction After Intraparenchymal Hemorrhage and Neurogenic Stunned Myocardium.
- Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
- Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
- Proteomic identification of the cerebral cavernous malformation signaling complex.
- Retrosigmoid suprafloccular transhorizontal fissure approach for resection of brainstem cavernous malformation.
- Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
- Spinal cavernous and capillary hemangiomas in adults.
- Surgical management of brainstem cavernomas: selection of approaches and microsurgical techniques.
- Symptomatic brainstem cavernomas.
- The presigmoid approach to anterolateral pontine cavernomas. Clinical article.
- Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.
- ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations.
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Keywords of People
- Vestal, Matthew, Assistant Professor of Neurosurgery, Pediatrics