Receptor Protein-Tyrosine Kinases
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Subject Areas on Research
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A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.
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A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.
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A small cell variant of ALK-positive, CD8-positive anaplastic large cell lymphoma with primary subcutaneous presentation mimicking subcutaneous panniculitis-like T-cell lymphoma.
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A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements.
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ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
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ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase".
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Abnormal pattern of Tie-2 and vascular endothelial growth factor receptor expression in human cerebral arteriovenous malformations.
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Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.
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Acanthosis nigricans: a practical approach to evaluation and management.
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Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.
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Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.
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Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.
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Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer.
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
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An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing.
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An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein.
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Angiogenesis.
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Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts.
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Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
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Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.
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Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers.
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CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.
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Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts.
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Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events?
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Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.
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Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.
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Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb.
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Clinical aspects of MuSK antibody positive seronegative MG.
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Clinical features of myasthenia gravis.
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Comment: Is 3,4-DAP a new option in treating MuSK MG?
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DNA copy number evolution in Drosophila cell lines.
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Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease.
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Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.
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Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.
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Desensitization of G protein-coupled receptors.
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Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
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Differential expression of VEGF isoforms in mouse during development and in the adult.
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Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
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Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: toward defining scarless versus scarring fibroblast phenotypes.
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Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.
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Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases.
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Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.
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Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.
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Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro.
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Does change in neuromuscular jitter predict or correlate with clinical change in MG?
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Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.
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Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat.
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Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.
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Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).
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Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.
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Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
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Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
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G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
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G protein-coupled receptor adaptation mechanisms.
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G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
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G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
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G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
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G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration.
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G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins.
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GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons.
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GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.
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Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
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Genomic structure of the EPHA1 receptor tyrosine kinase gene.
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HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.
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Heart rate decrease during crizotinib treatment and potential correlation to clinical response.
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Heptahelical receptor signaling: beyond the G protein paradigm.
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Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.
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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
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Imaging alternative splicing in living cells.
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Imaging molecular pathways: reporter genes.
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Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus.
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Inhibition of the erbB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides.
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Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.
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Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.
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Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.
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Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
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Lipid modifications of G-protein-coupled receptor kinases.
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MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb.
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Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.
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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
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Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.
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Molecular markers for incidence, prognosis, and response to therapy.
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Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.
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Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
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MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns.
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MuSK-antibody positive myasthenia gravis: questions from the clinic.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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Neurotrophin regulation of ionic currents and cell size depends on cell context.
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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades.
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Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma.
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Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas.
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PTEN reconstitution alters glioma responses to c-Met pathway inhibition.
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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
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Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
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Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
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Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
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Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization.
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Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
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Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3.
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Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A.
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Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
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Protein kinases that phosphorylate activated G protein-coupled receptors.
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Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay.
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Quantitative myasthenia gravis score: assessment of responsiveness and longitudinal validity.
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RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.
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RET polymorphisms and haplotypes and risk of differentiated thyroid cancer.
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RNAi-mediated PTB depletion leads to enhanced exon definition.
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Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
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Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
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Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
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Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
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Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system.
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Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium.
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Relationship of smoking and fibrosis in patients with chronic hepatitis C.
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Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.
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Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective review.
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Roles for Fgf signaling during zebrafish fin regeneration.
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Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.
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Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.
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Signaling in and out: control of cell division and differentiation in the shoot and root.
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Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
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Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
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Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
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Structure and mechanism of the G protein-coupled receptor kinases.
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Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.
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Synergy between tumor immunotherapy and antiangiogenic therapy.
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TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
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Targeting G protein-coupled receptor kinases to their receptor substrates.
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The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases.
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The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
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The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.
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The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
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The TOR signaling cascade regulates gene expression in response to nutrients.
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The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.
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The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.
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The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.
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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.
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The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.
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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
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Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
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Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury.
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Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases.
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Treatment Patterns for Advanced Non-Small-cell Lung Cancer After Platinum-containing Therapy in U.S. Community Oncology Clinical Practice.
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Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
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Tyrosine kinase inhibitors in renal cell carcinoma.
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Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.
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Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis.
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VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy?
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VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
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Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide.
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Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.
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pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Doan, Phuong Linh,
Assistant Professor of Medicine,
Duke Cancer Institute
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Stoecker, Maggie Marie,
Assistant Professor of Pathology,
Pathology
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Taylor, Gregory Alan,
Associate Professor in Medicine,
Immunology
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Yan, Hai,
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine,
Pathology