Receptor Protein-Tyrosine Kinases

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  Subject Areas on Research

  • A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. 
  • A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. 
  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. 
  • A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. 
  • A small cell variant of ALK-positive, CD8-positive anaplastic large cell lymphoma with primary subcutaneous presentation mimicking subcutaneous panniculitis-like T-cell lymphoma. 
  • A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. 
  • ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). 
  • ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. 
  • ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase". 
  • Abnormal pattern of Tie-2 and vascular endothelial growth factor receptor expression in human cerebral arteriovenous malformations. 
  • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. 
  • Acanthosis nigricans: a practical approach to evaluation and management. 
  • Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. 
  • An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. 
  • Angiogenesis. 
  • Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Association of Broad-Based Genomic Sequencing With Survival Among Patients With Advanced Non-Small Cell Lung Cancer in the Community Oncology Setting. 
  • Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. 
  • Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers. 
  • CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. 
  • Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study. 
  • Cabozantinib in ovarian clear cell cancers: UnMET expectations. 
  • Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts. 
  • Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events? 
  • Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis. 
  • Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. 
  • Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb. 
  • Clinical aspects of MuSK antibody positive seronegative MG. 
  • Clinical features of myasthenia gravis. 
  • Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred. 
  • Comment: Is 3,4-DAP a new option in treating MuSK MG? 
  • Congenital central hypoventilation syndrome: mutation analysis of the receptor tyrosine kinase RET. 
  • DNA copy number evolution in Drosophila cell lines. 
  • Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease. 
  • Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Desensitization of G protein-coupled receptors. 
  • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Differential expression of VEGF isoforms in mouse during development and in the adult. 
  • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. 
  • Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: toward defining scarless versus scarring fibroblast phenotypes. 
  • Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. 
  • Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. 
  • Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. 
  • Does change in neuromuscular jitter predict or correlate with clinical change in MG? 
  • Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. 
  • Epigenetic regulation of AXL and risk of childhood asthma symptoms. 
  • Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). 
  • Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. 
  • FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G protein-coupled receptor adaptation mechanisms. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. 
  • G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. 
  • GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons. 
  • GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. 
  • Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. 
  • Genomic structure of the EPHA1 receptor tyrosine kinase gene. 
  • Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. 
  • HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. 
  • Heart rate decrease during crizotinib treatment and potential correlation to clinical response. 
  • Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. 
  • Heptahelical receptor signaling: beyond the G protein paradigm. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • Imaging alternative splicing in living cells. 
  • Imaging molecular pathways: reporter genes. 
  • Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus. 
  • Inhibition of the erbB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides. 
  • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. 
  • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb. 
  • Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. 
  • Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. 
  • Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. 
  • MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury. 
  • Molecular markers for incidence, prognosis, and response to therapy. 
  • Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. 
  • Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns. 
  • MuSK-antibody positive myasthenia gravis: questions from the clinic. 
  • Muscle autoantibodies in myasthenia gravis: beyond diagnosis? 
  • Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease. 
  • Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. 
  • Odorant receptors and desensitization proteins colocalize in mammalian sperm. 
  • Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. 
  • Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas. 
  • PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. 
  • PTEN reconstitution alters glioma responses to c-Met pathway inhibition. 
  • Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. 
  • Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. 
  • Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. 
  • Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinases that phosphorylate activated G protein-coupled receptors. 
  • Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay. 
  • Quantitative myasthenia gravis score: assessment of responsiveness and longitudinal validity. 
  • RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. 
  • RET polymorphisms and haplotypes and risk of differentiated thyroid cancer. 
  • RNAi-mediated PTB depletion leads to enhanced exon definition. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. 
  • Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. 
  • Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. 
  • Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. 
  • Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. 
  • Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. 
  • Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. 
  • Relationship of smoking and fibrosis in patients with chronic hepatitis C. 
  • Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival. 
  • Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective review. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. 
  • Segregation at three loci explains familial and population risk in Hirschsprung disease. 
  • Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. 
  • Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. 
  • Signaling in and out: control of cell division and differentiation in the shoot and root. 
  • Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. 
  • Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. 
  • Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. 
  • Structure and mechanism of the G protein-coupled receptor kinases. 
  • Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. 
  • Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. 
  • Targeting G protein-coupled receptor kinases to their receptor substrates. 
  • The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases. 
  • The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. 
  • The TOR signal transduction cascade controls cellular differentiation in response to nutrients. 
  • The TOR signaling cascade regulates gene expression in response to nutrients. 
  • The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. 
  • The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. 
  • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. 
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. 
  • Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. 
  • Treatment Patterns for Advanced Non-Small-cell Lung Cancer After Platinum-containing Therapy in U.S. Community Oncology Clinical Practice. 
  • Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. 
  • Tyrosine kinase inhibitors in renal cell carcinoma. 
  • Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice. 
  • Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy? 
  • VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. 
  • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Doan, Phuong Linh, Assistant Professor of Medicine, Duke Cancer Institute
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology