Receptor, Platelet-Derived Growth Factor beta
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Subject Areas on Research
- A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
- Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.
- Effect of pazopanib on tumor microenvironment and liposome delivery.
- Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.
- Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression.
- G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.
- Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification.
- Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmatics.
- Initial testing of the multitargeted kinase inhibitor pazopanib by the Pediatric Preclinical Testing Program.
- Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.
- Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
- Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization.
- Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
- Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.
- Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
- Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition.
- The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
- Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
- Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor.
- Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.
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Keywords of People
- Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology