Receptor, trkB
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Subject Areas on Research
- A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
- ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
- Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB.
- Antiseizure effects of TrkB kinase inhibition.
- BCR-NTRK2 fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior.
- Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.
- CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.
- Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
- Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.
- Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
- Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.
- Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.
- Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death.
- Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation.
- Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus.
- LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.
- Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor.
- Mutual regulation of Src family kinases and the neurotrophin receptor TrkB.
- Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.
- Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma.
- Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus.
- Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
- Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast.
- Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.
- RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB.
- Rational basis for Trk inhibition therapy for prostate cancer.
- Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.
- Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.
- Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.
- Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.
- Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy.
- The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model.
- Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.
- Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.
- TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts.
- TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine.
- Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse.
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Keywords of People
- Jabba, Sairam V., Research Scientist, Anesthesiology