T-Box Domain Proteins

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  Subject Areas on Research

  • A novel model for IFN-γ-mediated autoinflammatory syndromes. 
  • Ambulatory impedance cardiography: a feasibility study. 
  • Brachyury expression in tailless Molgulid ascidian embryos. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. 
  • Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. 
  • Genome-wide association studies of the PR interval in African Americans. 
  • Hedgehog signaling patterns mesoderm in the sea urchin. 
  • Identification of a recurrent microdeletion at 17q23.1q23.2 flanked by segmental duplications associated with heart defects and limb abnormalities. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • LvTbx2/3: a T-box family transcription factor involved in formation of the oral/aboral axis of the sea urchin embryo. 
  • Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. 
  • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. 
  • Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. 
  • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. 
  • RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. 
  • T (brachyury) gene duplication confers major susceptibility to familial chordoma. 
  • T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • TBX3 Directs Cell-Fate Decision toward Mesendoderm. 
  • TBX5 is required for embryonic cardiac cell cycle progression. 
  • Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. 
  • Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon. 
  • The role of Brachyury (T) during gastrulation movements in the sea urchin Lytechinus variegatus. 
  • The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
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  Keywords of People

  • Shinohara, Mari L., Associate Professor of Immunology, Immunology