rap1 GTP-Binding Proteins
-
Subject Areas on Research
- A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.
- A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
- A role for G(z) in pancreatic islet beta-cell biology.
- Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
- Activation of Rap1 promotes prostate cancer metastasis.
- Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways.
- Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.
- Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
- Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
- POT1 association with TRF2 regulates telomere length.
- Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.
- Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.
- Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
- Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.
- Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
- Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
- The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.
- The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.