rac1 GTP-Binding Protein

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  Subject Areas on Research

  • A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 
  • Abl family kinases regulate endothelial barrier function in vitro and in mice. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. 
  • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Bacterial penetration of bladder epithelium through lipid rafts. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases 
  • Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p. 
  • Control of antiviral innate immune response by protein geranylgeranylation. 
  • Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. 
  • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. 
  • G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. 
  • Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. 
  • Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. 
  • Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. 
  • Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis. 
  • PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. 
  • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 
  • RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation. 
  • RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Regulation of local GTP availability controls RAC1 activity and cell invasion. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia. 
  • Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. 
  • Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. 
  • Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. 
  • Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. 
  • The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. 
  • The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. 
  • The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. 
  • Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. 
  • Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans. 
  • Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology