Protein Structure, Quaternary
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Subject Areas on Research
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A complete algorithm to resolve ambiguity for intersubunit NOE assignment in structure determination of symmetric homo-oligomers.
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A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs.
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A soybean G2 glycinin allergen. 2. Epitope mapping and three-dimensional modeling.
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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.
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Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
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Adenosine nucleotides and the regulation of GRP94-client protein interactions.
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Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
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African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.
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An estimate to the first approximation of microtubule rupture force.
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Blood traffic control.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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Characterization of a trimeric MPER containing HIV-1 gp41 antigen.
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Comparison of the physical and functional properties of the 48-subunit native molecule and the 24- and 12-subunit dissociation intermediates of Limulus polyphemus hemocyanin.
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Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor.
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Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore.
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Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae.
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Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
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Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation.
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Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation.
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Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.
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Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus.
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Curved FtsZ protofilaments generate bending forces on liposome membranes.
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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
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De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor.
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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.
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Development of human protein reference database as an initial platform for approaching systems biology in humans.
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Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.
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Direct observation of multimer stabilization in the mechanical unfolding pathway of a protein undergoing oligomerization.
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Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways.
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Dynamics of Forced Nucleosome Unraveling and Role of Nonuniform Histone-DNA Interactions
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Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
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Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.
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Evidence for conservation of architecture and physical properties of Omp85-like proteins throughout evolution.
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Extracellular superoxide dismutase exists as an octamer.
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Extracellular superoxide dismutase.
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Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.
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Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
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Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates.
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FtsZ filament capping by MciZ, a developmental regulator of bacterial division.
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Gamma-tubulin nucleation: template or protofilament?
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Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.
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How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1.
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Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
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Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.
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Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.
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Interactions of NO with hemoglobin: from microbes to man.
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Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.
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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
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Mechanism of the Class I KDPG aldolase.
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Molecular architecture of native HIV-1 gp120 trimers.
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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
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Monitoring of receptor dimerization using plasmonic coupling of gold nanoparticles.
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NAD+ modulates p53 DNA binding specificity and function.
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Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
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Phage display screening for peptides that inhibit polyglutamine aggregation.
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Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins.
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Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.
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Probing domain interactions in soluble guanylate cyclase.
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Protein secondary structure determination by constrained single-particle cryo-electron tomography.
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Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
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Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
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Rapid double 8-nm steps by a kinesin mutant.
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Real-time heterogeneous protein-protein interaction between αA-crystallin N-terminal mutants and αB-crystallin using quartz crystal microbalance (QCM).
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Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains.
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Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.
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Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.
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Ribosome-independent regulation of translocon composition and Sec61alpha conformation.
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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
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Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
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Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter.
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Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH.
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Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
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Structural characterization of the late competence protein ComFB from Bacillus subtilis.
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Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter.
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Structural insights into corepressor recognition by antagonist-bound estrogen receptors.
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Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
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Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation.
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Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.
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Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies.
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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
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Structure determination of symmetric homo-oligomers by a complete search of symmetry configuration space, using NMR restraints and van der Waals packing.
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Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
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Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly.
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Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.
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Structure of mammalian protein geranylgeranyltransferase type-I.
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Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate.
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Structure of the Haemophilus influenzae HMW1B translocator protein: evidence for a twin pore.
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Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter.
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Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy.
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Structures of partition protein ParA with nonspecific DNA and ParB effector reveal molecular insights into principles governing Walker-box DNA segregation.
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Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism.
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Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
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Surface loop dynamics in adeno-associated virus capsid assembly.
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Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation.
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The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX).
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The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
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The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.
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The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
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The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
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The dual nature of human extracellular superoxide dismutase: one sequence and two structures.
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The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein.
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The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
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The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
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Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.
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Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
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Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.
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Translocator proteins in the two-partner secretion family have multiple domains.
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Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
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Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.
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Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening.
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Visualization of arrestin recruitment by a G-protein-coupled receptor.
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XMAP215 is a long thin molecule that does not increase microtubule stiffness.
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Keywords of People