RNA Stability

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  Subject Areas on Research

  • 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states. 
  • A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency. 
  • A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. 
  • A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion. 
  • A potentially abundant junctional RNA motif stabilized by m6A and Mg2. 
  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. 
  • Acetylation takes aim at mRNA. 
  • An additional class of m⁶ A readers. 
  • Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation. 
  • Circular RNAs are abundant, conserved, and associated with ALU repeats. 
  • Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. 
  • Controlling mRNA stability and translation with the CRISPR endoribonuclease Csy4. 
  • Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors. 
  • Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells. 
  • EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. 
  • EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. 
  • Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation. 
  • Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress. 
  • High-Resolution Expression Map of the Arabidopsis Root Reveals Alternative Splicing and lincRNA Regulation. 
  • Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. 
  • Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. 
  • Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo. 
  • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes. 
  • Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs. 
  • Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis. 
  • Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. 
  • Minireview: global regulation and dynamics of ribonucleic Acid. 
  • Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling. 
  • Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. 
  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. 
  • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. 
  • N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs. 
  • N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. 
  • Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation. 
  • Neurotrophins: transcription and translation. 
  • Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. 
  • Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites. 
  • Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Probing RNA Conformational Equilibria within the Functional Cellular Context. 
  • RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. 
  • RNA-seq: impact of RNA degradation on transcript quantification. 
  • Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans. 
  • Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. 
  • Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. 
  • Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales. 
  • Structural determinants of insert retention of poliovirus expression vectors with recombinant IRES elements. 
  • Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. 
  • Suppression of the microRNA pathway by bacterial effector proteins. 
  • Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. 
  • The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. 
  • The global dynamics of RNA stability orchestrates responses to cellular activation. 
  • The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase. 
  • The secretory pathway in control of endoplasmic reticulum homeostasis. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • Tnni3k modifies disease progression in murine models of cardiomyopathy. 
  • Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli. 
  • Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. 
  • Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. 
  • XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability. 
  • Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. 
  • m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs. 
  • mRNA Metabolism in Cardiac Development and Disease: Life After Transcription. 
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  Keywords of People

  • Been, Michael Douglas, Professor Emeritus of Biochemistry, Biochemistry