Vigabatrin

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  Subject Areas on Research

  • Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. 
  • Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. 
  • Antiepileptogenesis and disease modification: Clinical and regulatory issues. 
  • Evidence implicating substantia nigra in regulation of kindled seizure threshold. 
  • Medical treatment of patients with infantile spasms. 
  • Simple high-performance liquid chromatographic method to monitor vigabatrin, and preliminary review of concentrations determined in epileptic patients. 
  • The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. 
  • Therapy of infantile spasms: new opportunities and emerging challenges.