Mitogen-Activated Protein Kinase Kinases
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Subject Areas on Research
- A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
- A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
- A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.
- Activation of MAP kinase by a dual specificity Tyr/Thr kinase.
- Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro.
- Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
- Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family.
- Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
- Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest.
- CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
- Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.
- Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.
- Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
- Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
- Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming.
- Copper is required for oncogenic BRAF signalling and tumorigenesis.
- Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
- Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.
- ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
- Elevated circulating tissue inhibitor of metalloproteinase 1 (TIMP-1) levels are associated with neuroendocrine differentiation in castration resistant prostate cancer.
- Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer.
- Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function.
- Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
- Functional expression of a MAP kinase kinase in COS cells and recognition by an anti-STE7/byr1 antibody.
- Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans.
- Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.
- Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.
- Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
- Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
- In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
- Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
- Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
- Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
- Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
- Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.
- Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
- Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
- Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.
- Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
- Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.
- Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
- MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
- Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition.
- Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells.
- Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.
- NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.
- Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
- Non-erythroid effects of erythropoietin.
- Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.
- Ordered phosphorylation of p42mapk by MAP kinase kinase.
- Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.
- Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
- Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3.
- Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.
- Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.
- Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
- ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer.
- Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle.
- Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
- Signal transduction. Three paths to stress relief.
- Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.
- Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth.
- Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
- Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
- The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
- The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.
- The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
- Trametinib (GSK1120212) in the treatment of melanoma.
- UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
- Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
- Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.