MAP Kinase Kinase Kinases
-
Subject Areas on Research
-
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
-
A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle.
-
A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma.
-
A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.
-
A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
-
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
-
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
-
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
-
Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
-
Cell-cycle control of cell polarity in yeast.
-
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
-
Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types.
-
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
-
Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling.
-
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
-
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
-
Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma.
-
Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion.
-
Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.
-
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
-
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
-
Inhibition of Cdc42 during mitotic exit is required for cytokinesis.
-
Inhibition of the cardiomyocyte-specific troponin I-interacting kinase limits oxidative stress, injury, and adverse remodeling due to ischemic heart disease.
-
Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
-
Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
-
Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
-
MEK inhibition in the treatment of advanced melanoma.
-
Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.
-
Mekk3 is essential for early embryonic cardiovascular development.
-
Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.
-
Modulation of pancreatic cancer chemoresistance by inhibition of TAK1.
-
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.
-
Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
-
PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans.
-
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.
-
Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.
-
Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.
-
Preclinical efficacy of MEK inhibition in Nras-mutant AML.
-
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.
-
Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation.
-
Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
-
Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.
-
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
-
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
-
TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.
-
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.
-
Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.
-
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
-
The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
-
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
-
The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.