MAP Kinase Signaling System
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Subject Areas on Research
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A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
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A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae.
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A common switch used by plants and animals.
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A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
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A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants.
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A mechanistic study of evolvability using the mitogen-activated protein kinase cascade.
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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
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A role for Pin1 in mammalian germ cell development and spermatogenesis.
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A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
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A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.
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ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
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Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.
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Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
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Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).
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Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.
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Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.
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Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.
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Alterations in human trabecular meshwork cell homeostasis by selenium.
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Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice.
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An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines.
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An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury.
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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.
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Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
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Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
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Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.
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Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
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Beta-arrestin-mediated signaling in the heart.
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Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
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Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling.
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
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CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.
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CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
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Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms.
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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
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Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.
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Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.
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Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
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Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
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Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.
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Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
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Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
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Complexity in endometrial estradiol signaling.
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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
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Conserved cAMP signaling cascades regulate fungal development and virulence.
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.
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Control of osteoblast regeneration by a train of Erk activity waves.
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Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
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Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer.
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Copper is required for oncogenic BRAF signalling and tumorigenesis.
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Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
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Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.
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Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.
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Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.
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DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
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Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK.
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Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.
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Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.
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Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues.
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Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells.
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Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
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Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.
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Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes.
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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
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Distinct requirements for Ras oncogenesis in human versus mouse cells.
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Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
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Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium.
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Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
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Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.
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Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer.
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Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.
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Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
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Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.
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Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway.
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Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy.
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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
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Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
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Focal Rosai-Dorfman disease coexisting with lymphoma in the same anatomic site: a localized histiocytic proliferation associated with MAPK/ERK pathway activation.
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Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.
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G Protein and β-arrestin signaling bias at the ghrelin receptor.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
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G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
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GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
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GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
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GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS.
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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
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Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity.
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Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.
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Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.
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Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
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Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.
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HIV-1 activates macrophages independent of Toll-like receptors.
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HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.
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Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1.
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Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.
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Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells.
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Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
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Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition?
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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
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IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.
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Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
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Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site.
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Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
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Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
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Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK.
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Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.
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Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.
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Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
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Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
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Insulin-like signalling to the maternal germline controls progeny response to osmotic stress.
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Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
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Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
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Intracellular signaling in primary sensory neurons and persistent pain.
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Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.
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Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.
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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
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Lefty proteins exhibit unique processing and activate the MAPK pathway.
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Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
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Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
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Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
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LncRNA-MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis-modulation of MAP3K4.
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
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Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway.
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MAP kinase and pain.
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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.
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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
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Manipulating JNK signaling with (--)-zuonin A.
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Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.
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Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.
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Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition.
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MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.
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Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells.
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Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.
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Mitogen-activated protein kinases 3 and 6 are required for full priming of stress responses in Arabidopsis thaliana.
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Mitogen-activated protein kinases in heart development and diseases.
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Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury.
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.
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Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
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Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
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Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
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Mutations of the BRAF gene in human cancer.
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.
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NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.
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Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX.
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Negative regulation of mTOR activation by diacylglycerol kinases.
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Neurohormonal regulation of pancreatic secretion.
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Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium.
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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades.
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Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
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Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.
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Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
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Overcoming MCL-1-driven adaptive resistance to targeted therapies.
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PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.
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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
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Pathogen virulence factors as molecular probes of basic plant cellular functions.
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Pathways of cell signaling in hyperoxia.
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Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.
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Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
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Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx.
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Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells.
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Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.
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Preclinical efficacy of MEK inhibition in Nras-mutant AML.
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Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
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Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
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RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
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ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer.
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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
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Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans.
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Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.
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Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
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Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
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Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.
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Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
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Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.
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Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
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Robustness and dissipation of mitogen-activated protein kinases signal transduction network: underlying funneled landscape against stochastic fluctuations.
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Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress.
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Role of mitogen-activated protein kinase in osteoblast differentiation.
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STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
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Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
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Sequestration of mitochondrial iron by silica particle initiates a biological effect.
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ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
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Signal transduction cascades regulating fungal development and virulence.
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Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.
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Signaling cross-talk between TGF-beta/BMP and other pathways.
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Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation.
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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
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Stress-specific activation mechanisms for the "cell integrity" MAPK pathway.
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Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair.
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Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.
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TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
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TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.
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Targeting astrocyte signaling for chronic pain.
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Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos.
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The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
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The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
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The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
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The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.
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The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.
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The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint.
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The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.
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The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis.
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The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
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The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
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The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.
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The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
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The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure.
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The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.
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The role and regulation of mTOR in T-lymphocyte function.
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The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.
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The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
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The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.
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Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.
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Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
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Trametinib (GSK1120212) in the treatment of melanoma.
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Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis.
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Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
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Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.
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TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.
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Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release.
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Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.
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Unisexual reproduction of Cryptococcus gattii.
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Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.
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Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
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Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.
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Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma.
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Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis.
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Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.
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XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.
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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
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beta-arrestins: traffic cops of cell signaling.
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p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
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p38 MAP kinases in the heart.
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p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Lew, Daniel Julio,
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology,
Cell Biology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
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Zennadi, Rahima,
Associate Professor in Medicine,
Pathology