MAP Kinase Signaling System

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  Subject Areas on Research

  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. 
  • A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. 
  • A common switch used by plants and animals. 
  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • A mechanistic study of evolvability using the mitogen-activated protein kinase cascade. 
  • A novel role for copper in Ras/mitogen-activated protein kinase signaling. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. 
  • Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. 
  • Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate. 
  • Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. 
  • Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk. 
  • Atorvastatin regulates apoptosis in chronically ischemic myocardium. 
  • Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. 
  • Beta-Arrestins: new roles in regulating heptahelical receptors' functions. 
  • Beta-Arrestins: new roles in regulating heptahelical receptors' functions. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestin-mediated signaling in the heart. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling. 
  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. 
  • CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. 
  • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. 
  • Conserved cAMP signaling cascades regulate fungal development and virulence. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. 
  • Depletion of plasma membrane cholesterol dampens hydrostatic pressure and shear stress-induced mechanotransduction pathways in osteoblast cultures. 
  • Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. 
  • Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. 
  • Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Distinct requirements for Ras oncogenesis in human versus mouse cells. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. 
  • Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor. 
  • Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia. 
  • G Protein and β-arrestin signaling bias at the ghrelin receptor. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. 
  • GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. 
  • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. 
  • Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • HIV-1 activates macrophages independent of Toll-like receptors. 
  • Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1. 
  • Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • Human lung innate immune response to Bacillus anthracis spore infection. 
  • IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. 
  • Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor. 
  • Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+. 
  • Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK. 
  • Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. 
  • Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. 
  • Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB. 
  • Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. 
  • Intracellular signaling in primary sensory neurons and persistent pain. 
  • KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • MAP kinase and pain. 
  • Manipulating JNK signaling with (--)-zuonin A. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP. 
  • MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. 
  • Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. 
  • Mutations of the BRAF gene in human cancer. 
  • NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. 
  • Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. 
  • Neurohormonal regulation of pancreatic secretion. 
  • Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium. 
  • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI. 
  • PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. 
  • Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle. 
  • Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells. 
  • Preclinical efficacy of MEK inhibition in Nras-mutant AML. 
  • Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. 
  • RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. 
  • RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. 
  • Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. 
  • Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. 
  • Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction. 
  • Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. 
  • Regulation of the metastasis suppressor gene MKK4 in ovarian cancer. 
  • Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. 
  • Robustness and dissipation of mitogen-activated protein kinases signal transduction network: underlying funneled landscape against stochastic fluctuations. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • Sequestration of mitochondrial iron by silica particle initiates a biological effect. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Signal transduction cascades regulating fungal development and virulence. 
  • Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. 
  • Signaling cross-talk between TGF-beta/BMP and other pathways. 
  • Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Stress-specific activation mechanisms for the "cell integrity" MAPK pathway. 
  • Systematic identification of signaling pathways with potential to confer anticancer drug resistance. 
  • TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. 
  • Targeting astrocyte signaling for chronic pain. 
  • The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. 
  • The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. 
  • The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. 
  • The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation. 
  • The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint. 
  • The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. 
  • The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 
  • The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. 
  • The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. 
  • The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. 
  • The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. 
  • The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach. 
  • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 
  • Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. 
  • Trametinib (GSK1120212) in the treatment of melanoma. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. 
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. 
  • Unisexual reproduction of Cryptococcus gattii. 
  • Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. 
  • beta-arrestins: traffic cops of cell signaling. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Lew, Daniel Julio, James B. Duke Professor of Pharmacology and Cancer Biology, Cell Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Zennadi, Rahima, Associate Professor in Medicine, Medicine, Hematology