Heterotrimeric GTP-Binding Proteins
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Subject Areas on Research
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A multigene family encoding a diverse array of putative pheromone receptors in mammals.
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Alfred Goodman Gilman (1941-2015).
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Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin.
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Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
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Beyond desensitization: physiological relevance of arrestin-dependent signaling.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
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Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
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Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
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Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
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Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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Defining G protein beta gamma specificity for effector recognition.
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Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils.
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Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube.
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Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.
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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
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Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.
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Fluorescent probes as indicators of conformation changes in transducin on activation.
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G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
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GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.
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Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.
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Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
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Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans.
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Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
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Genetic risk factors for perception of symptoms in GERD: an observational cohort study.
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Gz, a guanine nucleotide-binding protein with unique biochemical properties.
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Heptahelical terpsichory. Who calls the tune?
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Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
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Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study.
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Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
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Identification of putative direct effectors for G alpha o, using yeast two-hybrid method.
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Immunohistochemistry of the canine vomeronasal organ.
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Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
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Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
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Molecular basis for interactions of G protein betagamma subunits with effectors.
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Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
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Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
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Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.
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Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.
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Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.
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Purification of G protein beta gamma from bovine brain.
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Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
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RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex.
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RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
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Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.
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Regulation of G protein-coupled receptor signaling by scaffold proteins.
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Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors.
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Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains.
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Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.
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Seven-transmembrane receptor signaling through beta-arrestin.
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Seven-transmembrane receptors.
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Signal transduction. Bringing channels closer to the action!
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Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels.
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Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia.
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The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
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The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
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The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
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The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein.
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The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.
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The superfamily of heptahelical receptors.
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Transduction of receptor signals by beta-arrestins.
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Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
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Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
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beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
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mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.