Protein Transport

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  Subject Areas on Research

  • A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis. 
  • A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. 
  • A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. 
  • A conserved sorting-associated protein is mutant in chorea-acanthocytosis. 
  • A functional correlate of severity in alternating hemiplegia of childhood. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. 
  • A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs. 
  • A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes. 
  • A physical interaction network of dengue virus and human proteins. 
  • A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. 
  • A rapid and affordable screening platform for membrane protein trafficking. 
  • A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. 
  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. 
  • ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. 
  • ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. 
  • Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestins: multifunctional cellular mediators. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation. 
  • Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. 
  • Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Casein kinase I: from obscurity to center stage. 
  • Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cell polarization defects in early heart development. 
  • Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. 
  • Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans. 
  • Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. 
  • Characterization of the CaMKKβ-AMPK signaling complex. 
  • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 
  • Chemical waves in cell and developmental biology. 
  • Chlamydia effector proteins and new insights into chlamydial cellular microbiology. 
  • Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. 
  • Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Control of rice grain-filling and yield by a gene with a potential signature of domestication. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes. 
  • Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Development of a Grp94 inhibitor. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Dimer recognition and secretion by the ESX secretion system in Bacillus subtilis. 
  • Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. 
  • Directing traffic into the future. 
  • Disruption of a ciliary B9 protein complex causes Meckel syndrome. 
  • Distinct functions of POT1 at telomeres. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Duration of nuclear NF-kappaB action regulated by reversible acetylation. 
  • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamic regulation of phosphoinositide 3-kinase-gamma activity and beta-adrenergic receptor trafficking in end-stage human heart failure. 
  • EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. 
  • Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency. 
  • Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. 
  • Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 
  • Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Extracellular superoxide dismutase exists as an octamer. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target. 
  • FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis. 
  • Fluctuating vs. continuous exposure to H₂O₂: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. 
  • Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. 
  • G Protein and β-arrestin signaling bias at the ghrelin receptor. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome. 
  • Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. 
  • IKKα negatively regulates ASC-dependent inflammasome activation. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins. 
  • Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter. 
  • Incorporation of heterologous outer membrane and periplasmic proteins into Escherichia coli outer membrane vesicles. 
  • Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis. 
  • Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibition of Cdc42 during mitotic exit is required for cytokinesis. 
  • Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis. 
  • Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. 
  • Inhibition of the dopamine D1 receptor signaling by PSD-95. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Intercellular movement of the putative transcription factor SHR in root patterning. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. 
  • Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch. 
  • LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. 
  • LRRK2 secretion in exosomes is regulated by 14-3-3. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Light-driven translocation of signaling proteins in vertebrate photoreceptors. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. 
  • Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes. 
  • Low temperature and chemical rescue affect molecular proximity of DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC). 
  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. 
  • MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro. 
  • MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 
  • Mechanisms regulating SHORT-ROOT intercellular movement. 
  • Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. 
  • Mechanistic mathematical model of polarity in yeast. 
  • Methods to Visualize MAVS Subcellular Localization. 
  • Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. 
  • Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. 
  • Molecular defects underlying the Kell null phenotype. 
  • Molecular dissection of the checkpoint kinase Hsl1p. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. 
  • Myosin III illuminates the mechanism of arrestin translocation. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Ncd motor binding and transport in the spindle. 
  • Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Not just another hole in the wall: understanding intercellular protein trafficking. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. 
  • Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma. 
  • O-glycosylation as a sorting determinant for cell surface delivery in yeast. 
  • Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. 
  • Organization of enzyme concentration across the metabolic network in cancer cells. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. 
  • Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. 
  • Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Phytochrome signaling mechanisms and the control of plant development. 
  • Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. 
  • Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. 
  • Plasminogen activator inhibitor-1 regulates myoendothelial junction formation. 
  • Polarity establishment requires localized activation of Cdc42. 
  • Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. 
  • Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment. 
  • Protein Crowding within the Postsynaptic Density Can Impede the Escape of Membrane Proteins. 
  • Protein prenylation: unique fats make their mark on biology. 
  • Protein selection and export via outer membrane vesicles. 
  • Protein sorting, targeting and trafficking in photoreceptor cells. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • Pseudomonas syringae Effector Avirulence Protein E Localizes to the Host Plasma Membrane and Down-Regulates the Expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 Gene Required for Antibacterial Immunity in Arabidopsis. 
  • Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. 
  • Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density. 
  • R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. 
  • RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Reconstitution of contractile FtsZ rings in liposomes. 
  • Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Regulation of expression, activity and localization of fungal chitin synthases. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. 
  • Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. 
  • Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase. 
  • Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. 
  • Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome. 
  • RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. 
  • S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors. 
  • Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure. 
  • Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. 
  • Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates. 
  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Spatiotemporal signalling in plant development. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease. 
  • Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis. 
  • Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Suppression of interleukin-1 beta-induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase. 
  • T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. 
  • Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • Targeting protein localization for anti-infective therapy. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. 
  • The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The effects of amyloid precursor protein on postsynaptic composition and activity. 
  • The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. 
  • The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". 
  • The immunological properties of endoplasmic reticulum chaperones: a conflict of interest? 
  • The implication of AMPA receptor in synaptic plasticity impairment and intellectual disability in fragile X syndrome. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The secretory pathway in control of endoplasmic reticulum homeostasis. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • The translocation of HMGB1 during cell activation and cell death. 
  • The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins. 
  • The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. 
  • The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. 
  • Trafficking of G protein-coupled receptors. 
  • Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. 
  • Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. 
  • Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Tyrosine-dependent basolateral targeting of human connexin43-eYFP in Madin-Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V. 
  • TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. 
  • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction. 
  • Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation, and sequestration. 
  • Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. 
  • Visualizing receptor endocytosis and trafficking. 
  • Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. 
  • beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. 
  • beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta-arrestins: traffic cops of cell signaling. 
  • Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. 
  • β-Arrestin-mediated receptor trafficking and signal transduction. 
• 

  Keywords of People

  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Steinbach, William J., Professor of Pediatrics, Duke Innovation & Entrepreneurship