Protein Transport

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  Subject Areas on Research

  • A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis. 
  • A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. 
  • A bacterial virulence protein suppresses host innate immunity to cause plant disease. 
  • A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. 
  • A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity. 
  • A conserved sorting-associated protein is mutant in chorea-acanthocytosis. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. 
  • A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes. 
  • A physical interaction network of dengue virus and human proteins. 
  • A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. 
  • A rapid and affordable screening platform for membrane protein trafficking. 
  • A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. 
  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC. 
  • Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma. 
  • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestins: multifunctional cellular mediators. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation. 
  • Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. 
  • Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking. 
  • Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. 
  • Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans. 
  • Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. 
  • Characterization of the CaMKKβ-AMPK signaling complex. 
  • Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe. 
  • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 
  • Chemical waves in cell and developmental biology. 
  • Chlamydia effector proteins and new insights into chlamydial cellular microbiology. 
  • Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. 
  • Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Control of rice grain-filling and yield by a gene with a potential signature of domestication. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. 
  • Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Development of a Grp94 inhibitor. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Directing traffic into the future. 
  • Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection. 
  • Distinct functions of POT1 at telomeres. 
  • Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamic regulation of phosphoinositide 3-kinase-gamma activity and beta-adrenergic receptor trafficking in end-stage human heart failure. 
  • EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation. 
  • EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. 
  • ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. 
  • Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. 
  • Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. 
  • Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. 
  • Expression and distribution of voltage-gated ion channels in ferret sinoatrial node. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target. 
  • FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. 
  • Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. 
  • G Protein and β-arrestin signaling bias at the ghrelin receptor. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • How Diffusion Impacts Cortical Protein Distribution in Yeasts. 
  • Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. 
  • Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. 
  • IKKα negatively regulates ASC-dependent inflammasome activation. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins. 
  • Incorporation of heterologous outer membrane and periplasmic proteins into Escherichia coli outer membrane vesicles. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibition of Cdc42 during mitotic exit is required for cytokinesis. 
  • Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis. 
  • Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. 
  • Inhibition of the dopamine D1 receptor signaling by PSD-95. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Intercellular movement of the putative transcription factor SHR in root patterning. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. 
  • Kinesin walks the line: single motors observed by atomic force microscopy. 
  • Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch. 
  • Kinetics of protein import into isolated Xenopus oocyte nuclei. 
  • Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. 
  • LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. 
  • LRRK2 secretion in exosomes is regulated by 14-3-3. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Light-driven translocation of signaling proteins in vertebrate photoreceptors. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 
  • Mechanisms regulating SHORT-ROOT intercellular movement. 
  • Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. 
  • Mechanistic mathematical model of polarity in yeast. 
  • Methods to Visualize MAVS Subcellular Localization. 
  • Microtubule cross-linking triggers the directional motility of kinesin-5. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. 
  • Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. 
  • Molecular defects underlying the Kell null phenotype. 
  • Molecular dissection of the checkpoint kinase Hsl1p. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. 
  • Myosin III illuminates the mechanism of arrestin translocation. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Ncd motor binding and transport in the spindle. 
  • Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Not just another hole in the wall: understanding intercellular protein trafficking. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. 
  • Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma. 
  • O-glycosylation as a sorting determinant for cell surface delivery in yeast. 
  • Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. 
  • Organization of enzyme concentration across the metabolic network in cancer cells. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. 
  • Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. 
  • Pathogenic Bacteria Target Plant Plasmodesmata to Colonize and Invade Surrounding Tissues. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. 
  • Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. 
  • Polarity establishment requires localized activation of Cdc42. 
  • Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. 
  • Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. 
  • Protein prenylation: unique fats make their mark on biology. 
  • Protein selection and export via outer membrane vesicles. 
  • Protein sorting, targeting and trafficking in photoreceptor cells. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • Pseudomonas aeruginosa activates caspase 1 through Ipaf. 
  • Pseudomonas syringae Effector Avirulence Protein E Localizes to the Host Plasma Membrane and Down-Regulates the Expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 Gene Required for Antibacterial Immunity in Arabidopsis. 
  • Pseudomonas syringae pv. tomato DC3000 HopPtoM (CEL ORF3) is important for lesion formation but not growth in tomato and is secreted and translocated by the Hrp type III secretion system in a chaperone-dependent manner. 
  • Public funding of understanding nature. 
  • Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. 
  • R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Reconstitution of contractile FtsZ rings in liposomes. 
  • Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Regulation of expression, activity and localization of fungal chitin synthases. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis. 
  • Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans. 
  • Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. 
  • Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome. 
  • Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. 
  • RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. 
  • S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors. 
  • Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure. 
  • Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. 
  • Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates. 
  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. 
  • Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Spatiotemporal signalling in plant development. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stabilization of μ-opioid receptor facilitates its cellular translocation and signaling. 
  • Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis. 
  • Subcellular Localization of Pseudomonas syringae pv. tomato Effector Proteins in Plants. 
  • Subcellular localization and functional analysis of the Arabidopsis GTPase RabE. 
  • Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. 
  • T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. 
  • TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. 
  • Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • Targeting protein localization for anti-infective therapy. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. 
  • The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. 
  • The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. 
  • The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". 
  • The immunological properties of endoplasmic reticulum chaperones: a conflict of interest? 
  • The implication of AMPA receptor in synaptic plasticity impairment and intellectual disability in fragile X syndrome. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The secretory pathway in control of endoplasmic reticulum homeostasis. 
  • The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • The translocation of HMGB1 during cell activation and cell death. 
  • The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins. 
  • The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. 
  • Trafficking of G protein-coupled receptors. 
  • Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. 
  • Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. 
  • Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Type III protein secretion in plant pathogenic bacteria. 
  • Type III protein secretion mechanism in mammalian and plant pathogens. 
  • TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. 
  • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes. 
  • Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation, and sequestration. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. 
  • Visualizing receptor endocytosis and trafficking. 
  • WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient. 
  • Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. 
  • Wnt traffic from endoplasmic reticulum to filopodia. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. 
  • beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. 
  • beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta-arrestins: traffic cops of cell signaling. 
  • Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. 
  • β-Arrestin-mediated receptor trafficking and signal transduction. 
• 

  Keywords of People

  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Juvvadi, Praveen Rao, Associate Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Duke Innovation & Entrepreneurship