Active Transport, Cell Nucleus

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  Subject Areas on Research

  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • AgSwe1p regulates mitosis in response to morphogenesis and nutrients in multinucleated Ashbya gossypii cells. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Analysis of the cell cycle using Xenopus egg extracts. 
  • Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. 
  • Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. 
  • Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas. 
  • Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Efficiency, selectivity, and robustness of nucleocytoplasmic transport. 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin. 
  • Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. 
  • Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. 
  • Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. 
  • Methed-up FOXOs can't in-Akt-ivate. 
  • Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. 
  • Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. 
  • Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons. 
  • Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock. 
  • Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. 
  • Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. 
  • Nuclear transport kinetics in microarrays of nuclear envelope patches. 
  • Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • Organizing mRNA export. 
  • Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. 
  • PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. 
  • Phosphorylation-dependent control of ZIPK nuclear import is species specific. 
  • Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora. 
  • Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. 
  • Post-transcriptional RNA regulons affecting cell cycle and proliferation. 
  • Preparation and use of interphase Xenopus egg extracts. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Reconstitution of nuclear protein export in isolated nuclear envelopes. 
  • Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. 
  • The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B. 
  • The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. 
  • The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.