Membrane Microdomains

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  Subject Areas on Research

  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • Bacterial penetration of bladder epithelium through lipid rafts. 
  • Bacterial penetration of the mucosal barrier by targeting lipid rafts. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. 
  • Cell biology. Caveolae--not just craters in the cellular landscape. 
  • Cell surface F1Fo ATP synthase: a new paradigm? 
  • Cell surface polarization during yeast mating. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells. 
  • Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids. 
  • Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • Gender differences in cholesterol nucleation in native bile: estrogen is a potential contributory factor. 
  • Glutamate receptor dynamics in dendritic microdomains. 
  • Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. 
  • Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal. 
  • HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. 
  • Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. 
  • Jumping to rafts: gatekeeper role of bilayer elasticity. 
  • Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. 
  • Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Microdomain evolution on giant unilamellar vesicles. 
  • NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. 
  • Overview of membrane rafts. 
  • Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. 
  • Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. 
  • Perifosine: update on a novel Akt inhibitor. 
  • Phase separation in biological membranes: integration of theory and experiment. 
  • Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. 
  • Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. 
  • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayers. 
  • Rvs161p and sphingolipids are required for actin repolarization following salt stress. 
  • Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. 
  • Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Spine microdomains for postsynaptic signaling and plasticity. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Stepping between membrane microdomains. 
  • Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The role of lipid rafts in the pathogenesis of bacterial infections. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Virus particle release from glycosphingolipid-enriched microdomains is essential for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus. 
  • X-ray diffraction to determine the thickness of raft and nonraft bilayers. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Cell Biology