Cyclophilin A

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  Subject Areas on Research

  • Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. 
  • Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • HIV-1 infection: fooling the gatekeeper. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. 
  • Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. 
  • Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. 
  • Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. 
  • Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures. 
  • StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions. 
  • Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. 
  • Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate. 
  • Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. 
  • Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. 
  • Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. 
  • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. 
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  Keywords of People

  • Patz Jr., Edward F., James and Alice Chen Professor of Radiology, Pathology