Focal Adhesions
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Subject Areas on Research
- Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.
- Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
- Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
- Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration.
- Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
- Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.
- Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway.
- Effects of cholesterol-lowering statins on the aqueous humor outflow pathway.
- Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
- Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.
- Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials.
- Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains.
- FRET efficiency measurement in a molecular tension probe with a low-cost frequency-domain fluorescence lifetime imaging microscope.
- Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells.
- Growth of mesenchymal stem cells on electrospun type I collagen nanofibers.
- How vinculin regulates force transmission.
- Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions.
- Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
- Molecular-Scale Tools for Studying Mechanotransduction.
- Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.
- Orchestrating Airway Smooth Muscle Cell Migration: GMFγ Phosphorylation Is the Key.
- Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
- Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
- TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.
- The detection and role of molecular tension in focal adhesion dynamics.
- The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
- Tunable molecular tension sensors reveal extension-based control of vinculin loading.
- Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.
- Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.
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Keywords of People
- Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
- Hoffman, Brenton D., James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering, Biomedical Engineering
- Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics