Adherens Junctions
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Subject Areas on Research
- A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.
- A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension.
- ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
- Abl family kinases regulate endothelial barrier function in vitro and in mice.
- Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases.
- Adherens junctions and stem cells.
- Ankyrin-G Inhibits Endocytosis of Cadherin Dimers.
- Cell adhesion in epidermal development and barrier formation.
- Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection.
- Differential impairment of adherens-junction expression/phosphorylation after cardioplegia in diabetic versus non-diabetic patients.
- Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component.
- Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.
- FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.
- FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes.
- ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
- Implications of hypoxia on mucosal barrier function.
- Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow.
- Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
- Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation.
- Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm.
- Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment.
- Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.
- Rho1 regulates Drosophila adherens junctions independently of p120ctn.
- Shear-induced force transmission in a multicomponent, multicell model of the endothelium.
- Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens.
- The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.
- The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM.
- beta-Catenin protects the epidermis from mechanical stresses.
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Keywords of People
- Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute