Tacrolimus Binding Proteins

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  Subject Areas on Research

  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. 
  • Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. 
  • Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. 
  • Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. 
  • Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision. 
  • CRHBP polymorphisms predict chronic pain development following motor vehicle collision. 
  • Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. 
  • Characterization of immunophilins in the silkmoth Bombyx mori. 
  • Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. 
  • Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. 
  • DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder. 
  • Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays. 
  • Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk. 
  • FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. 
  • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. 
  • FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. 
  • FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. 
  • Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. 
  • Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. 
  • Gene disruption with PCR products in Saccharomyces cerevisiae. 
  • Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. 
  • Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. 
  • Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis. 
  • HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children. 
  • Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. 
  • Human immunodeficiency virus. Chaperoning a pathogen. 
  • Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function. 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. 
  • Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. 
  • Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. 
  • Multimodal regulation of E2F1 gene expression by progestins. 
  • Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. 
  • N-terminal extension changes the folding mechanism of the FK506-binding protein. 
  • No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision. 
  • Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure. 
  • Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. 
  • Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Selective inhibitors of the FK506-binding protein 51 by induced fit. 
  • Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children. 
  • Structure-based classification of 45 FK506-binding proteins. 
  • Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. 
  • TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. 
  • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. 
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Duke Innovation & Entrepreneurship