Chromosomes, Artificial, Bacterial
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Subject Areas on Research
- A physical map of the human Y chromosome.
- A physical map of the human genome.
- An SSLP marker-anchored BAC framework map of the mouse genome.
- An evaluation of the draft human genome sequence.
- Analysis of regulatory CD8 T cells in Qa-1-deficient mice.
- Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.
- Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus.
- Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms.
- De novo and complex imbalanced chromosomal rearrangements revealed by array CGH in a patient with an abnormal phenotype and apparently "balanced" paracentric inversion of 14(q21q23).
- Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
- Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia.
- Efficient assembly of de novo human artificial chromosomes from large genomic loci.
- Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P.
- Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.
- Genetic modifications of mouse proopiomelanocortin peptide processing.
- Genomic and genetic definition of a functional human centromere.
- Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach.
- Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
- Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
- Loss of cftr function leads to pancreatic destruction in larval zebrafish.
- Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes.
- Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility.
- Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans.
- Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays.
- Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
- Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.
- Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.
- The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
- The sequence of the human genome.
- Transfer of CD8+ T cell memory using Bcl-2 as a marker.
- c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo.
- piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice.
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Keywords of People
- Calakos, Nicole, Professor in Neurology, Duke Science & Society
- Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
- Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology