Chromosomes, Artificial, Bacterial

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  Subject Areas on Research

  • A physical map of the human Y chromosome. 
  • A physical map of the human genome. 
  • An SSLP marker-anchored BAC framework map of the mouse genome. 
  • An evaluation of the draft human genome sequence. 
  • Analysis of regulatory CD8 T cells in Qa-1-deficient mice. 
  • Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. 
  • Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. 
  • De novo and complex imbalanced chromosomal rearrangements revealed by array CGH in a patient with an abnormal phenotype and apparently "balanced" paracentric inversion of 14(q21q23). 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • Genetic modifications of mouse proopiomelanocortin peptide processing. 
  • Genomic and genetic definition of a functional human centromere. 
  • Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach. 
  • Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. 
  • Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. 
  • Loss of cftr function leads to pancreatic destruction in larval zebrafish. 
  • Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. 
  • Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. 
  • Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans. 
  • Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes. 
  • Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. 
  • The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. 
  • The sequence of the human genome. 
  • Transfer of CD8+ T cell memory using Bcl-2 as a marker. 
  • c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo. 
  • piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice. 
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  Keywords of People

  • Calakos, Nicole, Professor in Neurology, Duke Science & Society
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology