Thermogenesis

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  Subject Areas on Research

  • Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. 
  • Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. 
  • An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. 
  • BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. 
  • Beta-adrenergic receptors and regulation of energy expenditure: a family affair. 
  • Cellular Origins of Beige Fat Cells Revisited. 
  • Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual. 
  • Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. 
  • Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. 
  • G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. 
  • Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease. 
  • Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. 
  • Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. 
  • Making Biological Sense of GWAS Data: Lessons from the FTO Locus. 
  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 
  • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. 
  • Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. 
  • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. 
  • PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. 
  • Protein, weight management, and satiety. 
  • Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. 
  • Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. 
  • Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. 
  • The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment. 
  • The impact of short-term depot-medroxyprogesterone acetate treatment on resting metabolic rate. 
  • The thermogenic effect of thyroid hormone and its clinical implications. 
  • Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • Transcriptional brakes on the road to adipocyte thermogenesis. 
  • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. 
  • Tγδ17 cells build up the nerve. 
  • Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. 
  • ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology