Complementarity Determining Regions
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Subject Areas on Research
- A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.
- Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41.
- Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.
- Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.
- Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes.
- Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
- Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.
- Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation.
- Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage.
- Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.
- Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
- Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.
- Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.
- Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
- Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.
- HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.
- Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.
- Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
- Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1.
- Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
- Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation.
- Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide.
- Monitoring cellular immune responses to cancer immunotherapy.
- Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.
- Quantification of total T-cell receptor diversity by flow cytometry and spectratyping.
- Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis.
- Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
- Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.
- Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
- Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
- T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation.
- T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children.
- T-Cell recovery in adults and children following umbilical cord blood transplantation.
- TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis.
- Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells.
- Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen.
- Viral receptor-binding site antibodies with diverse germline origins.
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Keywords of People
- Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering