Allelic Imbalance

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  Subject Areas on Research

  • A whole-genome analysis of premature termination codons. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Evolution of a malaria resistance gene in wild primates. 
  • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 
  • Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation. 
  • High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer. 
  • Primary adenocarcinomas of the lung in nonsmokers show a distinct pattern of allelic imbalance. 
  • Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. 
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  Keywords of People

  • Alberts, Susan C., Robert F. Durden Professor of Biology, Duke Science & Society
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship