Transplantation Tolerance
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Subject Areas on Research
- A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
- A threshold for central T cell tolerance to an inducible serum protein
- Aberrant B-cell homeostasis in chronic GVHD.
- Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.
- Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model.
- Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors.
- Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
- Apoptotic Donor Cells in Transplantation.
- Apoptotic cell-based therapies for promoting transplantation tolerance.
- B cells and transplantation tolerance.
- B cells in transplant tolerance and rejection: friends or foes?
- Biomimetic nanoparticles for transplantation tolerance.
- CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.
- Cellular and molecular targeting for nanotherapeutics in transplantation tolerance.
- Challenges in therapeutic strategies for transplantation: where now from here?
- Clinical tolerance 2008.
- Clinical trials: where are we now?
- Composite tissue allotransplantation: current challenges.
- Composite tissue allotransplantation: past, present and future-the history and expanding applications of CTA as a new frontier in transplantation.
- Contemporary Strategies and Barriers to Transplantation Tolerance.
- Crosstalk Between T and B Cells in the Germinal Center After Transplantation.
- Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.
- Development of tolerogenic strategies in the clinic.
- Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.
- Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation.
- Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.
- ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
- Emerging approaches and technologies in transplantation: the potential game changers.
- Ethics in the quest for transplant tolerance.
- Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
- Evidence for a gene controlling the induction of transplantation tolerance.
- Heart xenograft survival with chimeric pig donors and modest immune suppression.
- Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance.
- Identification of a B cell signature associated with renal transplant tolerance in humans.
- Immunologic considerations in composite tissue transplantation: overview.
- Immunoregulation and tolerance.
- Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus.
- Impact of infection on transplantation tolerance.
- Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation.
- Induction of transplantation tolerance in non-human primate preclinical models.
- Innate Functions of Dendritic Cell Subsets in Cardiac Allograft Tolerance.
- Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions.
- Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma.
- Knowledge about transplantation tolerance gained in primates.
- Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly.
- Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.
- Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients.
- Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.
- Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
- Meteorology and tolerance.
- Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.
- Murine cytomegalovirus dissemination but not reactivation in donor-positive/recipient-negative allogeneic kidney transplantation can be effectively prevented by transplant immune tolerance.
- Nanoparticle Platforms for Antigen-Specific Immune Tolerance.
- Non-HLA antibodies in transplantation: when do they matter?
- Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts.
- Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.
- Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model.
- Optimizing the use of regulatory T cells in allotransplantation: recent advances and future perspectives.
- PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
- Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.
- Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
- Recent advances in immunosuppressive therapy for prevention of renal allograft rejection.
- Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance.
- Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.
- Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin.
- Science of composite tissue allotransplantation.
- Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.
- The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
- The effects of brain death and ischemia on tolerance induction are organ-specific.
- The induction of tolerance of renal allografts by adoptive transfer in miniature swine.
- The role of CD154 in organ transplant rejection and acceptance.
- Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.
- Treatment with immunotoxin.
- Unique aspects of rejection and tolerance in liver transplantation.
- Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patients.
- Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis?
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Keywords of People
- Markert, Mary Louise, Professor Emeritus of Pediatrics, Immunology