Antimicrobial Cationic Peptides

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  Subject Areas on Research

  • A kiss of death--proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection. 
  • A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. 
  • Activation of factor X by factor VIIa on monocyte cell surfaces. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • Anemia of inflammation: the cytokine-hepcidin link. 
  • Anemia of inflammation: the hepcidin link. 
  • Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. 
  • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. 
  • Closing the iron gate. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Cutaneous Burn Injury Modulates Urinary Antimicrobial Peptide Responses and the Urinary Microbiome. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • EGFR (trans)activation mediates IL-8 and distinct human antimicrobial peptide and protein production following skin injury. 
  • Effects of vitamin D supplementation on salivary immune responses during Marine Corps basic training. 
  • Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae. 
  • Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis. 
  • Forging a field: the golden age of iron biology. 
  • Francisella FlmX broadly affects lipopolysaccharide modification and virulence. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepcidin and disordered mineral metabolism in chronic kidney disease. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. 
  • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. 
  • Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. 
  • Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. 
  • Innate immunity and antimicrobial defense systems in psoriasis. 
  • Interleukin-6 induces hepcidin expression through STAT3. 
  • Iron homeostasis and erythropoiesis. 
  • Iron homeostasis and inherited iron overload disorders: an overview. 
  • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. 
  • Late stage erythroid precursor production is impaired in mice with chronic inflammation. 
  • Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. 
  • Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia. 
  • Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations. 
  • Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms. 
  • Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. 
  • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. 
  • Outer Membrane Vesiculation Facilitates Surface Exchange and In Vivo Adaptation of Vibrio cholerae. 
  • Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. 
  • Pathophysiologic mechanisms of anemia of chronic disease. 
  • Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. 
  • Proinflammatory state, hepcidin, and anemia in older persons. 
  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. 
  • Review: Collectins link innate and adaptive immunity in allergic airway disease. 
  • Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. 
  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth. 
  • The ins and outs of iron homeostasis. 
  • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. 
  • The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. 
  • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. 
  • Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF. 
  • Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers. 
  • Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
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  Keywords of People

  • MacLeod, Amanda S, Adjunct Associate Professor in the Department of Dermatology, Integrative Immunobiology