Models, Animal

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  Subject Areas on Research

  • A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. 
  • A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays. 
  • A biomechanical, radiologic, and clinical comparison of outcome after multilevel cervical laminectomy or laminoplasty in the rabbit. 
  • A biophysical model for cardiac microimpedance measurements. 
  • A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 
  • A catheter based method to activate urethral sensory nerve fibers. 
  • A comparative study of retinal effects from continuous wave and femtosecond mode-locked lasers. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A model of muscle atrophy using cast immobilization in mice. 
  • A mouse model engineered to conditionally express the progesterone receptor-B isoform. 
  • A murine model of hyperdopaminergic state displays altered respiratory control. 
  • A new technique allowing prolonged temporary cerebral artery occlusion. 
  • A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy. 
  • A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. 
  • A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. 
  • A novel urodynamic model for lower urinary tract assessment in awake rats. 
  • A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway. 
  • A small animal model of regional alveolar ventilation using HP 3He MRI1. 
  • A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. 
  • A tale of two species: Neural integration in zebrafish and monkeys. 
  • A voltammetric and mathematical analysis of histaminergic modulation of serotonin in the mouse hypothalamus. 
  • A zebrafish model of germ cell aneuploidy. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists. 
  • Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata. 
  • Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish. 
  • Adolescent Intermittent Alcohol Exposure: Deficits in Object Recognition Memory and Forebrain Cholinergic Markers. 
  • Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models. 
  • Advantages of minimally invasive, balloon-dissector-assisted tissue expander placement: a clinical and experimental study. 
  • Age as an independent risk factor for severity of experimental choroidal neovascularization. 
  • Age-related changes affect rat rotator cuff muscle function. 
  • Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. 
  • Aligning animal models with clinical epilepsy: where to begin? 
  • Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. 
  • Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. 
  • American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice. 
  • Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation. 
  • An Eclectic Review of the History of Peripheral Nerve Surgery. 
  • An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. 
  • An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. 
  • An allogenic cell-based implant for meniscal lesions. 
  • An automatic experimental apparatus to study arm reaching in New World monkeys. 
  • An isolated working heart system for large animal models. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • Anatomic compression caused by high-volume convection-enhanced delivery to the brain. 
  • Animal models of steatosis. 
  • Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): comparisons with electroconvulsive shock (ECS). 
  • Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation. 
  • Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. 
  • Antithrombotic effect of ticlopidine in an experimental model of retinal vein occlusion. 
  • Apixaban Versus Warfarin for Mechanical Heart Valve Thromboprophylaxis in a Swine Aortic Heterotopic Valve Model. 
  • Approximating transcranial magnetic stimulation with electric stimulation in mouse: a simulation study. 
  • Aquatic models, genomics and chemical risk management. 
  • Aqueous humor outflow: what do we know? Where will it lead us? 
  • Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. 
  • Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. 
  • Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. 
  • Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model. 
  • Assessment of four tissue models on knot tensile strength. 
  • Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model. 
  • Attracting students to surgical careers: preclinical surgical experience. 
  • Attrition of memory CD8 T cells during sepsis requires LFA-1. 
  • Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. 
  • B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells. 
  • B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • Bariatric Embolization: Pilot Study on the Impact of Gastroprotective Agents and Arterial Distribution on Ulceration Risk and Efficacy in a Porcine Model. 
  • Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. 
  • Behavioral and Social Research to Accelerate the Geroscience Translation Agenda. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Bioethical, Reproducibility, and Translational Challenges of Animal Models. 
  • Biological basis of bone formation, remodeling, and repair-part III: biomechanical forces. 
  • Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants. 
  • Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. 
  • Botulinum Neurotoxin A injections influence stretching of the gastrocnemius muscle-tendon unit in an animal model. 
  • Bovine thrombin: history, use, and risk in the surgical patient. 
  • Building and maintaining the epithelium of the lung. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Caenorhabditis elegans as an emerging model system in environmental epigenetics. 
  • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. 
  • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. 
  • Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. 
  • Cardiac rupture after myocardial infarction: new insights from murine models. 
  • Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane. 
  • Cataract formation in a strain of rats selected for high oxidative stress. 
  • Cellular models of hibernating myocardium: implications for future research. 
  • Changes in the production of IL-10 and TNF-alpha in skeletal muscle of rats with heart failure secondary to acute myocardial infarction. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Circadian rhythm in larval release by the crab Rhithropanopeus harrisii: entrainment model. 
  • Combined bone allograft and adipose-derived stem cell autograft in a rabbit model. 
  • Commensal Microbiota Regulate Vertebrate Innate Immunity-Insights From the Zebrafish. 
  • Complete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria. 
  • Composite tissue allotransplantation: development of a preclinical model in nonhuman primates. 
  • Composite tissue transplantation: a rapidly advancing field. 
  • Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. 
  • Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. 
  • Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development. 
  • Controlled survival study of the effects of Tisseel or a combination of FloSeal and Tisseel on major vascular injury and major collecting-system injury during partial nephrectomy in a porcine model. 
  • Crossing the bridge: large animal models in translational transplantation research. 
  • D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. 
  • Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors. 
  • Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor. 
  • Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle. 
  • Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. 
  • Development of a 4-D digital mouse phantom for molecular imaging research. 
  • Developmental origins and environmental influences--Introduction. NIEHS symposium. 
  • Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans. 
  • Diabetic nephropathy: of mice and men. 
  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. 
  • Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. 
  • Differential effects of delta9-THC on learning in adolescent and adult rats. 
  • Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. 
  • Does minocycline have antidepressant effect? 
  • Dominance rank causally affects personality and glucocorticoid regulation in female rhesus macaques. 
  • Drosophila egg-laying site selection as a system to study simple decision-making processes. 
  • Dual lumen transducer probes for real-time 3-D interventional cardiac ultrasound. 
  • Early ethanol consumption predicts relapse-like behavior in adolescent male rats. 
  • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. 
  • Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. 
  • Effect of a nitric oxide donor on microcirculation of acutely denervated skeletal muscle during reperfusion. 
  • Effect of freeze time during renal cryoablation: a swine model. 
  • Effect of optical clearing agents on the in vivo optical properties of squamous epithelial tissue. 
  • Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. 
  • Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. 
  • Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. 
  • Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. 
  • Effects of long-term denervation on skeletal muscle in old rats. 
  • Effects of model-based iterative reconstruction on image quality for low-dose computed tomographic angiography of the thoracic aorta in a Swine model. 
  • Effects of phentermine and phenformin on biomarkers of aging in rats. 
  • Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulation. 
  • Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. 
  • Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. 
  • Elevated intrahepatic pressures and decreased hepatic tissue blood flow prevent gas embolus during limited laparoscopic liver resections. 
  • Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. 
  • Establishment of a critical-sized alveolar defect in the rat: a model for human gingivoperiosteoplasty. 
  • Establishment of multi-stage intravenous self-administration paradigms in mice. 
  • Estimating network parameters from combined dynamics of firing rate and irregularity of single neurons. 
  • Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model. 
  • Evaluation of cold ischemia for preservation of testicular function during partial orchiectomy in the rat model. 
  • Evidence that SOX2 overexpression is oncogenic in the lung. 
  • Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction. 
  • Experimental animal models of pancreatic carcinogenesis and metastasis. 
  • Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue. 
  • Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. 
  • Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Focal electrically administered seizure therapy: a novel form of ECT illustrates the roles of current directionality, polarity, and electrode configuration in seizure induction. 
  • Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results. 
  • Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. 
  • Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography. 
  • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. 
  • Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats. 
  • Functional significance of erythropoietin receptor expression in breast cancer. 
  • Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young. 
  • Gender differences in cholesterol nucleation in native bile: estrogen is a potential contributory factor. 
  • Gene expression phenotypes of oncogenic signaling pathways. 
  • Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. 
  • Genetic dissection of the mouse CNS using magnetic resonance microscopy. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression. 
  • Genomics and clinical medicine: rationale for creating and effectively evaluating animal models. 
  • Getting the inside tract: new frontiers in zebrafish digestive system biology. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • Guidance of cardiac pacemaker leads using real time 3D ultrasound: feasibility studies. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • Hand-assisted laparoscopic donor nephrectomy: analysis of the learning curve in a training model in vivo. 
  • Heart fatty acid binding protein as a marker for postmortem detection of early myocardial damage. 
  • Heart xenograft survival with chimeric pig donors and modest immune suppression. 
  • High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster. 
  • High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats. 
  • Human children, but not great apes, become socially closer by sharing an experience in common ground. 
  • Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. 
  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. 
  • Hypoxia of the growing liver accelerates regeneration. 
  • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. 
  • Immunotherapy of malignant brain tumors. 
  • Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. 
  • Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. 
  • Impact of genetic polymorphisms on heart failure prognosis. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Implanted electrodes for multi-month EEG. 
  • Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model. 
  • Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. 
  • In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. 
  • Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. 
  • Increased yield of endothelial cells from peripheral blood for cell therapies and tissue engineering. 
  • Increasing Blood Pressure by Greater Splanchnic Nerve Stimulation: a Feasibility Study. 
  • Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly. 
  • Induction of transplantation tolerance in non-human primate preclinical models. 
  • Initial Evaluation of a Novel Modulated Radiofrequency-based Bladder Denervation Device. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Injury-induced changes in liver specific transcription factors HNF-1α and HNF-4α. 
  • Insights into the evolution of social systems and species from baboon studies. 
  • Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics 
  • Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health. 
  • Interleukin-15 receptor blockade in non-human primate kidney transplantation. 
  • Intraoperative assessment of critical biliary structures with visible range/infrared image fusion. 
  • Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology. 
  • Introduction to zebrafish: current discoveries and emerging technologies for neurobehavioral toxicology and teratology. 
  • Invited commentary. 
  • Iron homeostasis: insights from genetics and animal models. 
  • Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death. 
  • Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds. 
  • Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy. 
  • Lack of p53 induction in fish cells by model chemotherapeutics. 
  • Lattice animal model of chromosome organization 
  • Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression. 
  • Lentiviral mediated gene delivery to the anterior chamber of rodent eyes. 
  • Life history context of reproductive aging in a wild primate model. 
  • Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images. 
  • Lipomatosis of Nerve and Neuromuscular Choristoma: Two Rare Entities and Their Call for an Animal Model to Understand and Mitigate Nerve-Territory Sequelae. 
  • Live volumetric imaging (LVI) intracardiac ultrasound catheter. 
  • Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. 
  • Local delivery of osteopontin attenuates vascular remodeling by altering matrix metalloproteinase-2 in a rabbit model of aortic injury. 
  • Long-term in vivo imaging of multiple organs at the single cell level. 
  • Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. 
  • Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands. 
  • Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. 
  • Marmoset vocal communication: Behavior and neurobiology. 
  • Mast cell activators as novel immune regulators. 
  • Maternal and Breast Milk Influences on the Infant Gut Microbiome, Enteric Health and Growth Outcomes of Rhesus Monkeys. 
  • Matrix Metalloproteinases and Glaucoma Treatment. 
  • Measuring Intraventricular Pressure Using Ultrasound Elastography. 
  • Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model. 
  • Mechanical analysis of rat trabecular meshwork. 
  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. 
  • Meeting report: high-throughput technologies for in vivo imaging agents. 
  • Methods for embryo dissociation and analysis of cell adhesion. 
  • Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. 
  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. 
  • Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion. 
  • Microvascularization of the hypermineralized calcified fibrocartilage and cortical bone in the sheep proximal femur. 
  • Microvolt T wave alternans inducibility in normal newborn puppies: effects of development. 
  • Microwave versus saline-linked radiofrequency (Aquamantys) assisted liver resection in a porcine liver resection model. A safety and feasibility pilot study. 
  • Middle ear packing: comparison of materials in an animal model of mucosal trauma. 
  • Mollusks as Multidisciplinary Models in Environmental Toxicology 
  • Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors. 
  • Mouse model of OPRM1 (A118G) polymorphism has altered hippocampal function. 
  • Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. 
  • Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. 
  • Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. 
  • Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish. 
  • Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. 
  • Murine model of oropharyngeal gastric fluid aspiration-A new assessment method for intrapulmonary liquid distribution using digital pixel calculation. 
  • Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. 
  • Mutational fingerprints of aging. 
  • Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. 
  • Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. 
  • NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. 
  • Near infrared laser-tissue welding using nanoshells as an exogenous absorber. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Neurological injury during cardiopulmonary bypass in the rat. 
  • Neuropharmacology of TBI-induced plasticity. 
  • Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model. 
  • Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model. 
  • New insights into the role of antinuclear antibodies in systemic lupus erythematosus. 
  • New roles of carboxypeptidase E in endocrine and neural function and cancer. 
  • Nicotinic involvement in memory function in zebrafish. 
  • Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. 
  • Non-model model organisms. 
  • Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. 
  • Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates. 
  • Nonhuman primates for the study of composite tissue allotransplantation. 
  • Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury. 
  • Novel Scoring Criteria for the Evaluation of Ocular Graft-versus-Host Disease in a Preclinical Allogeneic Hematopoietic Stem Cell Transplantation Animal Model. 
  • Novel emboli protection cannula during cardiac surgery: first animal study. 
  • One more way that mice and men are different. 
  • Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio). 
  • Optimal pressure of abdominal gas insufflation for bleeding control in a severe swine splenic injury model. 
  • Optimization of a murine immunization model for study of PF4/heparin antibodies. 
  • Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia. 
  • Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice. 
  • Ovarian effects of a high lactose diet in the female rat. 
  • Ovine model for engineering bone segments. 
  • Oxidative Stress and Total Antioxidant Status During Internal Carotid Artery Clamping with or without Shunting: An Experimental Pilot Study. 
  • P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. 
  • PI3K/Akt and apoptosis: size matters. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. 
  • Pathologic evaluation of hemostatic agents in percutaneous nephrolithotomy tracts in a porcine model. 
  • Pathophysiology of the blood-brain barrier: animal models and methods. 
  • Pediatric cardiovascular safety: challenges in drug and device development and clinical application. 
  • Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome? 
  • Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy. 
  • Pharmacological analyses of learning and memory in zebrafish (Danio rerio). 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Physiological Genomics: Who we are and where we're going. 
  • Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction. 
  • Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. 
  • Postmarket evaluation of breakthrough technologies. 
  • Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. 
  • Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model. 
  • Preparation of animals for use in the laboratory: issues and challenges for the Institutional Animal Care and Use Committee (IACUC). 
  • Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure. 
  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. 
  • Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts. 
  • Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. 
  • Psychophysical measurement of marmoset acuity and myopia. 
  • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. 
  • Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. 
  • Quantitative assessment of cervical softening during pregnancy in the Rhesus macaque with shear wave elasticity imaging. 
  • Quantitative neuromorphometry using magnetic resonance histology. 
  • Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole. 
  • RADAR realistic animal model series for dose assessment. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model. 
  • Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells. 
  • Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. 
  • Radiation-associated kidney injury. 
  • Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose. 
  • Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS). 
  • Real-time three-dimensional transesophageal echocardiography for guiding interventional electrophysiology: feasibility study. 
  • Recombinant tissue plasminogen activator injected into the vitreous cavity may penetrate the retinal veins of a porcine model of vascular occlusion. 
  • Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. 
  • Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models. 
  • Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application. 
  • Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling. 
  • Regulation of NFkappaB in hepatic ischemic preconditioning. 
  • Reproductive behavior in wild baboons. 
  • Resolving mechanisms of toxicity while pursuing ecotoxicological relevance? 
  • Rhesus macaques form preferences for brand logos through sex and social status based advertising. 
  • Sampling port for real-time analysis of bioaerosol in whole body exposure system for animal aerosol model development. 
  • Science of composite tissue allotransplantation. 
  • Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. 
  • Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Sensitivity of spiral computed tomography scanning for detecting intraocular foreign bodies. 
  • Sensor spacing affects the tissue impedance spectra of rabbit ventricular epicardium. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Single-port cholecystectomy with the TransEnterix SPIDER: simple and safe. 
  • Sirtuin-1 expression and activity is diminished in aged liver grafts. 
  • Spatial heterogeneity of the restitution portrait in rabbit epicardium. 
  • Stemming Lung Disease? 
  • Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells. 
  • Stress affects uterine receptivity through an ovarian-independent pathway. 
  • Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. 
  • Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the Syrian golden hamster. Part II. Results of chronic exposure. 
  • Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the syrian golden hamster. Part I. Results of a subchronic study and dose selection for a chronic study. 
  • Study of the role of CCR5 in a mouse model of intranasal challenge with Yersinia pestis. 
  • Subcutaneous infusion of human C1 inhibitor in swine. 
  • Summary of FDA antibody-mediated rejection workshop. 
  • Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates. 
  • Survival and inflammatory responses in experimental models of hemorrhage. 
  • Susceptibility to pancreatitis related to PSTI/SPINK1 expression. 
  • System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors. 
  • Systematic mapping of the monkey inferior colliculus reveals enhanced low frequency sound representation. 
  • Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models. 
  • Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. 
  • Temperatures achieved in human and canine neocortex during intraoperative passive or active focal cooling. 
  • Tempering allorecognition to induce transplant tolerance with chemically modified apoptotic donor cells. 
  • Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. 
  • Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. 
  • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. 
  • The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. 
  • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. 
  • The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. 
  • The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage. 
  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps. 
  • The effects of the apoE4 genotype on the developing mouse retina. 
  • The future of preclinical animal models in pharmaceutical discovery and development: a need to bring in cerebro to the in vivo discussions. 
  • The generation of extracellular DNA in SLE: the role of death and sex. 
  • The genome of a songbird. 
  • The immune system and developmental programming of brain and behavior. 
  • The intestinal lymph fistula model--a novel approach to study ghrelin secretion. 
  • The molecular basis for ethnic variation and histological subtype differences in prostate cancer. 
  • The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. 
  • The pathobiology of vascular malformations: insights from human and model organism genetics. 
  • The restitution portrait: a new method for investigating rate-dependent restitution. 
  • The role of alpha-synuclein in Parkinson's disease: insights from animal models. 
  • The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. 
  • The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes. 
  • The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis. 
  • The social neuroendocrinology of human aggression. 
  • The specificity of motor neurone regeneration (preferential reinnervation). 
  • The tardigrade Hypsibius dujardini, a new model for studying the evolution of development. 
  • The transient relationship between pressure and volume in the pediatric pulmonary system. 
  • The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model. 
  • The use of an inexpensive processing aid device (the Mouse PAD) to facilitate rodent tissue banking. 
  • The zebrafish as a model for complex tissue regeneration. 
  • Thoracic and lumbar spinal impact tolerance. 
  • Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation. 
  • Tonopen measurement of intraocular pressure in mice. 
  • Topography, cell response, and nerve regeneration. 
  • Toward an animal model for antisocial behavior: parallels between mice and humans. 
  • Tracing Self-Reactive B Cells in Normal Mice. 
  • Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. 
  • Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium. 
  • Transgenic mice as a tool to study the renin-angiotensin system. 
  • Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. 
  • Two Realistic Beagle Models for Dose Assessment. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • Use of magnets in gastrointestinal surgery. 
  • Use of medaka in toxicity testing. 
  • Using 4-vinylcyclohexene diepoxide as a model of menopause for cardiovascular disease. 
  • Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. 
  • VEGF as a Paracrine Regulator of Conventional Outflow Facility. 
  • Viability assessment by delayed enhancement cardiovascular magnetic resonance: will low-dose dobutamine dull the shine? 
  • Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells. 
  • Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex. 
  • Vulnerable windows for developmental ethanol toxicity in the Japanese medaka fish (Oryzias latipes). 
  • Wild-type Kras expands and exhausts hematopoietic stem cells. 
  • Xenobiotic metabolism and transport in Caenorhabditis elegans . 
  • Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. 
  • Zebrafish developmental screening of the ToxCast™ Phase I chemical library. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
  • dictyBase, the model organism database for Dictyostelium discoideum. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. 
• 

  Keywords of People

  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Arepally, Gowthami Morey, Professor of Medicine, Pathology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • James, Michael Lucas, Professor of Anesthesiology, Anesthesiology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Oristian, Kristi, Research Technician II, Pharmacology & Cancer Biology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Schmehl, Meredith, Student, Neurobiology
  • Segars, William Paul, Associate Professor in Radiology, Radiology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology