HIV Fusion Inhibitors
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Subject Areas on Research
- A prospective clinical and pathological examination of injection site reactions with the HIV-1 fusion inhibitor enfuvirtide.
- Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
- Chemokine (C-C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naive individuals.
- Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus.
- Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes.
- Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure.
- HIV entry inhibitors: progress in development and application.
- HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.
- In vitro and clinical investigation of the relationship between CCR5 receptor occupancy and anti-HIV activity of Aplaviroc.
- Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor.
- Key references in infectious diseases pharmacotherapy.
- Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children.
- Newer treatments for HIV in children.
- Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships.
- Safety and efficacy of enfuvirtide for 48 weeks as part of an optimized antiretroviral regimen in pediatric human immunodeficiency virus 1-infected patients.
- Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
- The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?