Collagen Type II

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  Subject Areas on Research

  • A large kindred of early-onset osteoarthritis of the knee and hip: excluding the link to COL2A1 gene. 
  • A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis. 
  • A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. 
  • Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis. 
  • Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. 
  • Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • Biaxial strain effects on cells from the inner and outer regions of the meniscus. 
  • Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study. 
  • Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. 
  • Body Mass Index and Type 2 Collagen Turnover in Individuals After Anterior Cruciate Ligament Reconstruction. 
  • COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. 
  • Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. 
  • First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis. 
  • Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. 
  • Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family. 
  • Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces. 
  • Low- Versus High-Intensity Plyometric Exercise During Rehabilitation After Anterior Cruciate Ligament Reconstruction. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Multilayered electrospun scaffolds for tendon tissue engineering. 
  • Mutant IDH is sufficient to initiate enchondromatosis in mice. 
  • Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes. 
  • Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome. 
  • PIIANP and HELIXII diurnal variation. 
  • Precocious osteoarthritis in a family with recurrent COL2A1 mutation. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • Reduced penetrance in a large Caucasian pedigree with Stickler syndrome. 
  • Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden. 
  • TCDD disrupts hypural skeletogenesis during medaka embryonic development. 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. 
  • The use of autologous adult, allogenic juvenile, and combined juvenile-adult cartilage fragments for the repair of chondral defects. 
  • Type II collagen gene variants and inherited osteonecrosis of the femoral head. 
  • Type II collagen markers in osteoarthritis: what do they indicate? 
  • Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis. 
  • Variation in osteoarthritis biomarkers from activity not food consumption. 
  • Xanthine oxidase injurious response in acute joint injury.