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Subject Areas on Research
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A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO.
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A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.
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Acetylation of mitochondrial proteins.
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Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.
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Actions of steroids in mitochondria.
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Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy.
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Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.
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Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
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Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
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Adrenoceptors, uncoupling proteins, and energy expenditure.
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Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism.
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Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae.
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BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
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Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism.
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Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation.
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Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae.
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CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis.
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CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.
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Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe.
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Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.
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Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans.
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Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.
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Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.
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Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice.
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.
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Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.
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Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.
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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.
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Disruption of the Ang II type 1 receptor promotes longevity in mice.
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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.
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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors.
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Dystonia with and without deafness is caused by TIMM8A mutation.
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Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.
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Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia.
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Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages.
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Energy metabolism in uncoupling protein 3 gene knockout mice.
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Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.
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Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
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Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
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Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
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Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.
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Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
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Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring.
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Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
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Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
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Genomic characterization of POS5, the Saccharomyces cerevisiae mitochondrial NADH kinase.
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Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.
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HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.
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Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
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Human pluripotent stem cells decouple respiration from energy production.
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IAP proteins: sticking it to Smac.
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Incongruence between primary sequence data and the distribution of a mitochondrial atp1 group II intron among ferns and horsetails
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Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy.
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Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
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Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
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Inhibitor of apoptosis proteins as intracellular signaling intermediates.
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LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein.
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Lack of association between autism and SLC25A12.
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Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
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Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes.
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Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.
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Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
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Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice.
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
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Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.
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Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever.
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Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM.
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Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes.
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Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy.
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Mitochondrial FtsZ in a chromophyte alga
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Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.
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Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
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Mitochondrial adaptations to obesity-related oxidant stress.
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Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
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Mitochondrial protein acetylation regulates metabolism.
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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
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Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver.
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Mitochondrial sirtuins.
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Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control".
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Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.
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Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
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Muscle oxidative capacity during IL-6-dependent cancer cachexia.
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Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.
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Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion.
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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A.
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Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31.
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Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.
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Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.
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Oxygen flux analysis to understand the biological function of sirtuins.
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PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.
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PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle.
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PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
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Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.
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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.
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Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
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Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
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Postlipopolysaccharide oxidative damage of mitochondrial DNA.
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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
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Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
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Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.
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Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
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RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts.
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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
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RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.
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Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
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Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.
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Regulation of mitochondrial processes by protein S-nitrosylation.
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Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
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Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines.
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Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.
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Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
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Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.
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Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation.
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Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.
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Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A.
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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.
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SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.
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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
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SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
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SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder.
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
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Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
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Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice.
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Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice.
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Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
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Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei.
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Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
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Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise.
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Support for a monophyletic Lemuriformes: Overcoming incongruence between data partitions
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Survival in critical illness is associated with early activation of mitochondrial biogenesis.
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
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The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.
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The Arabidopsis sn-1-specific mitochondrial acylhydrolase AtDLAH is positively correlated with seed viability.
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The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
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The binding of SLE autoantibodies to mitochondria.
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The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.
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The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
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Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
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Towards a new classification of the Arthoniales (Ascomycota) based on a three-gene phylogeny focussing on the genus Opegrapha.
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Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation.
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Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver.
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UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.
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Upstream regulatory role for XIAP in receptor-mediated apoptosis.
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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
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XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
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beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.
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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
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p53 overexpression in advanced-stage endometrial adenocarcinoma.
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β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
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Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology