Transcription Initiation Site

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  Subject Areas on Research

  • A transcription factor affinity-based code for mammalian transcription initiation. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Architecture of the human regulatory network derived from ENCODE data. 
  • Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. 
  • Computational analysis of core promoters in the Drosophila genome. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Human promoters are intrinsically directional. 
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 
  • Identification of core promoter modules in Drosophila and their application in accurate transcription start site prediction. 
  • Identification of the promoter region of the human betaIGH3 gene. 
  • Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE. 
  • Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships. 
  • Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. 
  • Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. 
  • Paired-end analysis of transcription start sites in Arabidopsis reveals plant-specific promoter signatures. 
  • Pol II docking and pausing at growth and stress genes in C. elegans. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Promoting developmental transcription. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Structural basis of core promoter recognition in a primitive eukaryote. 
  • The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. 
  • The accessible chromatin landscape of the human genome. 
  • Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. 
  • [PCR amplification and structural analysis of two paralogous rat estrogen sulfotransferase genes] 
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  Keywords of People

  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship