Myosin Type II

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  Subject Areas on Research

  • A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. 
  • Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. 
  • Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. 
  • Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. 
  • Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. 
  • Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. 
  • Simultaneous stretching and contraction of stress fibers in vivo. 
  • Simultaneous stretching and contraction of stress fibers in vivo. 
  • Stimulation of Acanthamoeba actomyosin ATPase activity by myosin-II polymerization. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology