Genes, BRCA2

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  Subject Areas on Research

  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • Adherence to Recommended Risk Management among Unaffected Women with a BRCA Mutation. 
  • An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. 
  • Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. 
  • BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. 
  • BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. 
  • Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers. 
  • Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. 
  • Changes in diet and physical activity following BRCA1/2 testing. 
  • Characterization of BRCA1 and BRCA2 mutations in a large United States sample. 
  • Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. 
  • Comparing Mammography Abnormality Features to Genetic Variants in the Prediction of Breast Cancer in Women Recommended for Breast Biopsy. 
  • Coping with genetic testing for breast cancer susceptibility. 
  • DNA patents and diagnostics: not a pretty picture. 
  • Ductal carcinoma in situ in BRCA mutation carriers. 
  • Evaluation and optimisation of indel detection workflows for ion torrent sequencing of the BRCA1 and BRCA2 genes. 
  • Feasibility of breast duct lavage performed by a physician extender. 
  • Genetic testing in ovarian cancer: getting better, and maybe not just for disease susceptibility anymore. 
  • Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. 
  • Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. 
  • Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics. 
  • Genomic tests for ovarian cancer detection and management. 
  • Impact that Timing of Genetic Mutation Diagnosis has on Surgical Decision Making and Outcome for BRCA1/BRCA2 Mutation Carriers with Breast Cancer. 
  • Individualized survival curves improve satisfaction with cancer risk management decisions in women with BRCA1/2 mutations. 
  • Interest in BRCA1/2 testing in a primary care population. 
  • Limited family structure and breast cancer risk. 
  • Male breast cancer during treatment with leuprolide for prostate cancer. 
  • Molecular evolution of a Drosophila homolog of human BRCA2. 
  • Molecular testing for the BRCA1 and BRCA2 Ashkenazi Jewish founder mutations: a report on the College of American Pathologists proficiency testing surveys. 
  • Moving Beyond "Isolated" Gene Patents 
  • PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer. 
  • Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer. 
  • Pre-counseling education materials for BRCA testing: does tailoring make a difference? 
  • Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer. 
  • Psychological distress and quality of life associated with genetic testing for breast cancer risk. 
  • Randomized trial of a decision aid for BRCA1/BRCA2 mutation carriers: impact on measures of decision making and satisfaction. 
  • Risk of metachronous breast cancer after BRCA mutation-associated ovarian cancer. 
  • Role of genetic polymorphisms and ovarian cancer susceptibility. 
  • Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. 
  • Single-port risk-reducing salpingo-oophorectomy with and without hysterectomy: surgical outcomes and learning curve analysis. 
  • Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. 
  • Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. 
  • Targeted composite value-based endpoints in platinum-sensitive recurrent ovarian cancer. 
  • Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach. 
  • Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer. 
  • Validity of models for predicting BRCA1 and BRCA2 mutations. 
  • Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology