Potassium Channels, Voltage-Gated
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Subject Areas on Research
- 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
- A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology.
- A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom.
- A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
- Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.
- Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2.
- Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore.
- Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
- Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve-Month Postoperative Pain and Disability Outcomes.
- Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management.
- Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.
- Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
- ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.
- GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.
- Genetic modifiers of the Kv beta2-null phenotype in mice.
- Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism.
- Inner ear abnormalities in a Kcnq1 (Kvlqt1) knockout mouse: a model of Jervell and Lange-Nielsen syndrome.
- Kv3.1b is a novel component of CNS nodes.
- Learning and memory impairments in Kv beta 1.1-null mutants are rescued by environmental enrichment or ageing.
- MinK-dependent internalization of the IKs potassium channel.
- Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
- Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome.
- Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome.
- Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
- Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle.
- Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.
- Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
- The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons.
- Therapeutic Implications of Peripheral Nerve Hyperexcitability in Muscle Cramping: A Retrospective Review.
- Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.
- Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels.
- Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus.