Drug Resistance, Bacterial

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  Subject Areas on Research

  • 10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. 
  • A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. 
  • A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit. 
  • A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion. 
  • A Multicountry Molecular Analysis of Salmonella enterica Serovar Typhi With Reduced Susceptibility to Ciprofloxacin in Sub-Saharan Africa. 
  • A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis. 
  • A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. 
  • A novel diagnostic approach may reduce inappropriate antibiotic use for acute respiratory infections. 
  • Acute otitis media: bunnies, disposables, and bacterial original sin! 
  • Advances in basic and translational tuberculosis research: Proceedings of the first meeting of RePORT international. 
  • Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. 
  • Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group. 
  • Adverse consequences of neonatal antibiotic exposure. 
  • An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. 
  • Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of Neisseria gonorrhoeae: a modelling study. 
  • Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms. 
  • Antibacterial resistance leadership group: open for business. 
  • Antibiotic development - economic, regulatory and societal challenges. 
  • Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. 
  • Antibiotic stewardship: reassessment of guidelines for management of neonatal sepsis. 
  • Antibiotic use and misuse in the neonatal intensive care unit. 
  • Antibiotic-resistant bacteria on personal devices in hospital intensive care units: Molecular approaches to quantifying and describing changes in the bacterial community of personal mobile devices. 
  • Antibiotics as a selective driver for conjugation dynamics. 
  • Antimicrobial resistance trends and outbreak frequency in United States hospitals. 
  • Antimicrobial stewardship and infection prevention-leveraging the synergy: A position paper update. 
  • Antimicrobial stewardship programs in community hospitals: the evidence base and case studies. 
  • Antimicrobial stewardship programs: how to start and steer a successful program. 
  • Antimicrobial stewardship: a matter of process or outcome? 
  • Applying ecological resistance and resilience to dissect bacterial antibiotic responses. 
  • Bacteremia in lung transplant recipients in the current era. 
  • Bacterial conversion of folinic acid is required for antifolate resistance. 
  • Bacterial infections in Lilongwe, Malawi: aetiology and antibiotic resistance. 
  • Bacteriologic features of surgical site infections following breast surgery. 
  • Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study. 
  • Broad host range vectors for stable genomic library construction. 
  • Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients. 
  • Carbapenems for surgical prophylaxis? 
  • Changing epidemiology of serious bacterial infections in febrile infants without localizing signs. 
  • Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae. 
  • Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study. 
  • Collective antibiotic tolerance: mechanisms, dynamics and intervention. 
  • Colonization With Levofloxacin-resistant Extended-spectrum β-Lactamase-producing Enterobacteriaceae and Risk of Bacteremia in Hematopoietic Stem Cell Transplant Recipients. 
  • Combating antimicrobial resistance: policy recommendations to save lives. 
  • Community-acquired MRSA infections in North Carolina children: prevalence, antibiotic sensitivities, and risk factors. 
  • Comparison of microscan broth microdilution, synergy quad plate agar dilution, and disk diffusion screening methods for detection of high-level aminoglycoside resistance in enterococcus species. 
  • Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. 
  • Controlling antimicrobial resistance in the hospital. 
  • Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria. 
  • Current best practices and guidelines. Assessment and management of complications in infective endocarditis. 
  • Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolones. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. 
  • Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. 
  • Daptomycin: a rapidly bactericidal lipopeptide for the treatment of Gram-positive infections. 
  • Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR). 
  • Detection of inducible clindamycin resistance in staphylococci by broth microdilution using erythromycin-clindamycin combination wells. 
  • Direct-from-blood RNA sequencing identifies the cause of post-bronchoscopy fever. 
  • Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics. 
  • Effect of trimethoprim-sulfamethoxazole prophylaxis on antimicrobial resistance of fecal Escherichia coli in HIV-infected patients in Tanzania. 
  • Efficacy of anti-pseudomonal antibiotics: need to reconsider the empirical use of cefepime. 
  • Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen. 
  • Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India. 
  • Emerging options for treatment of invasive, multidrug-resistant Staphylococcus aureus infections. 
  • Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study. 
  • Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli. 
  • Epidemiology and risk factors for endemic typhoid fever in Uzbekistan. 
  • Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. 
  • Exogenous reinfection of tuberculosis in a low-burden area. 
  • Expert Consensus on Metrics to Assess the Impact of Patient-Level Antimicrobial Stewardship Interventions in Acute-Care Settings. 
  • Extensively drug-resistant tuberculosis: are we learning from history or repeating it? 
  • Facilitation of robust growth of Prochlorococcus colonies and dilute liquid cultures by "helper" heterotrophic bacteria. 
  • Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients. 
  • From the Centers for Disease Control and Prevention. Disseminated infection with Simiae-avium group mycobacteria in persons with AIDS--Thailand and Malawi, 1997. 
  • Generation of ramoplanin-resistant Staphylococcus aureus. 
  • Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group. 
  • Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group. 
  • Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients. 
  • Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review. 
  • History of antibiotics: from fluoroquinolones to daptomycin (Part 2). 
  • Iclaprim: a differentiated option for the treatment of skin and skin structure infections. 
  • Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. 
  • In vitro activity of amikacin against isolates of Mycobacterium avium complex with proposed MIC breakpoints and finding of a 16S rRNA gene mutation in treated isolates. 
  • In vitro activity of telithromycin against macrolide-susceptible and macrolide-resistant pharyngeal isolates of group A streptococci in the United States. 
  • Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin. 
  • Infected bilomas in liver transplant recipients, incidence, risk factors and implications for prevention. 
  • Infective endocarditis caused by daptomycin-resistant Enterococcus faecalis: a case report. 
  • Intermittent tuberculosis treatment for patients with isoniazid intolerance or drug resistance. 
  • Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. 
  • Invasive gram-positive bacterial infection in cancer patients. 
  • Invasive non-Typhi Salmonella disease in Africa. 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007). 
  • Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda. 
  • MASTERMIND: Bringing Microbial Diagnostics to the Clinic. 
  • Measuring the effect of inappropriate initial antibiotic therapy on outcomes of patients with Gram-negative sepsis: An imprecise science. 
  • Methicillin-resistant Staphylococcus aureus: an evolving pathogen. 
  • Microbial inactivation of Pseudomonas putida and Pichia pastoris using gene silencing. 
  • Microbiology of ventilator-associated pneumonia compared with that of hospital-acquired pneumonia. 
  • Molecular Diagnostics for Mycobacterium tuberculosis Infection. 
  • Molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals Intergenus KPC carbapenemase transmission through a promiscuous plasmid. 
  • Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. 
  • Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. 
  • Multicenter study to determine disk diffusion and broth microdilution criteria for prediction of high- and low-level mupirocin resistance in Staphylococcus aureus. 
  • Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USA. 
  • Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. 
  • Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. 
  • National Department of Defense surveillance data for antibiotic resistance and emm gene types of clinical group A streptococcal isolates from eight basic training military sites. 
  • National survey on the susceptibility of Bacteroides Fragilis Group: report and analysis of trends for 1997-2000. 
  • National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004. 
  • Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy. 
  • New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance. 
  • Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions. 
  • Pathogen flow: what we need to know. 
  • Patient and physician attitudes regarding risk and benefit in streamlined development programmes for antibacterial drugs: a qualitative analysis. 
  • Pediatric-specific antimicrobial susceptibility data and empiric antibiotic selection. 
  • Persistence and reversal of plasmid-mediated antibiotic resistance. 
  • Population-based surveillance of typhoid fever in Egypt. 
  • Predictors of fluoroquinolone-resistant bacteria in the rectal vault of men undergoing prostate biopsy. 
  • Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae. 
  • Prevalence, antibiotic resistance and molecular characterisation of Staphylococcus aureus in pigs at agricultural fairs in the USA. 
  • Rapid molecular detection of tuberculosis and rifampin resistance. 
  • Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 
  • Reevaluating fluoroquinolone breakpoints for Salmonella enterica serotype Typhi and for non-Typhi salmonellae. 
  • Reevaluation of Clinical and Laboratory Standards Institute disk diffusion breakpoints for tetracyclines for testing Enterobacteriaceae. 
  • Reply to Phillips, Morris, and Walker. 
  • Research needs in antibiotic stewardship. 
  • Resistance diagnosis and the changing economics of antibiotic discovery. 
  • Resistance diagnosis and the changing epidemiology of antibiotic resistance. 
  • Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. 
  • Sequential emergence of antibiotic resistance in enterococcal bloodstream isolates over 25 years. 
  • Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. 
  • Staphylococcus aureus bacteremia and endocarditis. 
  • Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria. 
  • Structure, inhibition, and regulation of essential lipid A enzymes. 
  • Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network. 
  • Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe. 
  • Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria. 
  • Telavancin. 
  • Telavancin: a new lipoglycopeptide for gram-positive infections. 
  • The Antibacterial Resistance Leadership Group: Progress Report and Work in Progress. 
  • The Mandate for a Global "One Health" Approach to Antimicrobial Resistance Surveillance. 
  • The Role of Stewardship in Addressing Antibacterial Resistance: Stewardship and Infection Control Committee of the Antibacterial Resistance Leadership Group. 
  • The incidence of fluoroquinolone resistant infections after prostate biopsy--are fluoroquinolones still effective prophylaxis? 
  • The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. 
  • The potential for community exposures to pathogens from an urban dairy. 
  • The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. 
  • Tigecycline disk diffusion breakpoints of Acinetobacter spp.: a clinical point of view. 
  • Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance. 
  • Transcription-associated mutation of lasR in Pseudomonas aeruginosa. 
  • Transforming Concepts Into Clinical Trials and Creating a Multisite Network: The Leadership and Operations Center of the Antibacterial Resistance Leadership Group. 
  • Vital signs: improving antibiotic use among hospitalized patients. 
  • White paper: recommendations on the conduct of superiority and organism-specific clinical trials of antibacterial agents for the treatment of infections caused by drug-resistant bacterial pathogens. 
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  Keywords of People

  • Boggan, Joel, Assistant Professor of Medicine, Medicine, General Internal Medicine
  • Moehring, Rebekah, Associate Professor of Medicine, Medicine, Infectious Diseases
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology