Molecular Diagnostic Techniques

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  Subject Areas on Research

  • A RT-PCR assay for the detection of coronaviruses from four genera. 
  • A quality control program within a clinical trial Consortium for PCR protocols to detect Plasmodium species. 
  • A rationale for conducting parallel mechanistic studies in clinical trials of pharmacotherapy. 
  • Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group. 
  • Advancing the boundaries of molecular imaging. 
  • An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model. 
  • Better tests, better care: improved diagnostics for infectious diseases. 
  • Biomarkers for amyotrophic lateral sclerosis. 
  • Block-diagonal discriminant analysis and its bias-corrected rules. 
  • Cancer characterization and feature set extraction by discriminative margin clustering. 
  • Clinical application of exome sequencing in undiagnosed genetic conditions. 
  • Clinical genomic testing: getting it right. 
  • Comparative effectiveness research and demonstrating clinical utility for molecular diagnostic tests. 
  • Comparison of commercial influenza A virus assays in detecting avian influenza H7N9 among poultry cloacal swabs, China. 
  • Cost-Effectiveness of High-Risk Human Papillomavirus Testing With Messenger RNA Versus DNA Under United States Guidelines for Cervical Cancer Screening. 
  • Detection of occult N2 disease with molecular techniques. 
  • Detection of pathogen-specific antibodies by loop-mediated isothermal amplification. 
  • Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia. 
  • Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis. 
  • Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus. 
  • Developments in Molecular Testing and Biosimilars. 
  • Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort. 
  • Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles. 
  • Discussing Health Care Expenses in the Oncology Clinic: Analysis of Cost Conversations in Outpatient Encounters. 
  • Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. 
  • Genes with bimodal expression are robust diagnostic targets that define distinct subtypes of epithelial ovarian cancer with different overall survival. 
  • Getting small is suddenly very big: review of the proceedings of the third annual meeting of the Society for Molecular Imaging. 
  • Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases. 
  • Immune profiling: molecular monitoring in renal transplantation. 
  • Impact of molecular testing on reported Clostridoides difficile infection rates. 
  • Impact of multiple policy interventions on the screening and diagnosis of drug-resistant tuberculosis patients: a cascade analysis on six prefectures in China. 
  • Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches. 
  • Individualizing treatment decisions for older adults with hematologic malignancies. 
  • Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care. 
  • Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancer. 
  • Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases. 
  • MOLECULAR PROGNOSTICS FOR UVEAL MELANOMA. 
  • Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens. 
  • Molecular genetic testing and the future of clinical genomics. 
  • Molecular malaria epidemiology: mapping and burden estimates for the Democratic Republic of the Congo, 2007. 
  • Multicenter evaluation of the LightCycler methicillin-resistant Staphylococcus aureus (MRSA) advanced test as a rapid method for detection of MRSA in nasal surveillance swabs. 
  • Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay. 
  • Multiplex 5' nuclease quantitative real-time PCR for clinical diagnosis of malaria and species-level identification and epidemiologic evaluation of malaria-causing parasites, including Plasmodium knowlesi. 
  • NCCN Clinical Practice Guidelines Occult primary. 
  • New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance. 
  • Non-small cell lung cancer. 
  • Performance of diagnostic tests to detect respiratory viruses in older adults. 
  • Personalized targeted therapy for esophageal squamous cell carcinoma. 
  • Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. 
  • Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV. 
  • Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II. 
  • Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections--needs, advances, and future prospects. 
  • Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics. 
  • Seeing into cells. The promise of in vivo molecular imaging in oncology. 
  • Serum biomarker panels for the detection of pancreatic cancer. 
  • Simultaneous detection of major drug resistance mutations in the protease and reverse transcriptase genes for HIV-1 subtype C by use of a multiplex allele-specific assay. 
  • Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. 
  • Study protocol for a cluster-randomized trial to compare human papillomavirus based cervical cancer screening in community-health campaigns versus health facilities in western Kenya. 
  • Systematic review of the performance of HIV viral load technologies on plasma samples. 
  • Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus. 
  • Targeted Re-Sequencing Emulsion PCR Panel for Myopathies: Results in 94 Cases. 
  • The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis. 
  • The complexities of Xpert® MTB/RIF interpretation. 
  • The current epidemiology and clinical decisions surrounding acute respiratory infections. 
  • The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. 
  • The host response as a tool for infectious disease diagnosis and management. 
  • The integration of molecular diagnostics with therapeutics. Implications for drug development and pathology practice. 
  • The value of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration. 
  • Translating genomic biomarkers into clinically useful diagnostics. 
  • Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology