Principal Component Analysis

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  Subject Areas on Research

  • 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture. 
  • A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis. 
  • A comparison of two spirituality instruments and their relationship with depression and quality of life in chronic heart failure. 
  • A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. 
  • A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting. 
  • A limited-angle intrafraction verification (LIVE) system for radiation therapy. 
  • A new fully automated approach for aligning and comparing shapes. 
  • A planning quality evaluation tool for prostate adaptive IMRT based on machine learning. 
  • A polygenic p factor for major psychiatric disorders. 
  • A real-time spike classification method based on dynamic time warping for extracellular enteric neural recording with large waveform variability. 
  • A technique for estimating 4D-CBCT using prior knowledge and limited-angle projections. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet. 
  • Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences. 
  • Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. 
  • Alternative pay-for-performance scoring methods: implications for quality improvement and patient outcomes. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • An information-theoretic criterion for intrasubject alignment of FMRI time series: motion corrected independent component analysis. 
  • Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission. 
  • Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. 
  • Ancient West African foragers in the context of African population history. 
  • Archaic and modern human distal humeral morphology. 
  • Assessing the effects of silver nanoparticles on biological nutrient removal in bench-scale activated sludge sequencing batch reactors. 
  • Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. 
  • Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. 
  • Autofluorescence and diffuse reflectance properties of malignant and benign breast tissues. 
  • Automatic detection of omissions in medication lists. 
  • BSS-based filtering of physiological and ARFI-induced tissue and blood motion. 
  • Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation. 
  • Biomarkers Associated with Physical Resilience After Hip Fracture. 
  • Biomechanical implications of intraspecific shape variation in chimpanzee crania: moving toward an integration of geometric morphometrics and finite element analysis. 
  • Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. 
  • Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. 
  • C-reactive protein is associated with psychological risk factors of cardiovascular disease in apparently healthy adults. 
  • Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. 
  • Chemography of natural product space. 
  • Classification of finger pairs from one hand based on spectral features in human EEG. 
  • Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. 
  • Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol. 
  • Comparative functional morphology of the primate peroneal process. 
  • Comparing neighborhoods of adults with serious mental illness and of the general population: research implications. 
  • Comparison of multiexcitation fluorescence and diffuse reflectance spectroscopy for the diagnosis of breast cancer (March 2003). 
  • Competition for hummingbird pollination shapes flower color variation in Andean solanaceae. 
  • Complex principal components for robust motion estimation. 
  • Complexities associated with the molecular and proteomic identification of Paecilomyces species in the clinical mycology laboratory. 
  • Comprehensive Characterization of Cancer Driver Genes and Mutations. 
  • Conformational Dynamics of Mechanically Compliant DNA Nanostructures from Coarse-Grained Molecular Dynamics Simulations. 
  • Context-dependent categorical perception in a songbird. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Coping and quality of life in patients awaiting lung transplantation. 
  • Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia. 
  • Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates. 
  • Correlations between physical and chemical defences in plants: tradeoffs, syndromes, or just many different ways to skin a herbivorous cat? 
  • Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy. 
  • DNA methylation alterations in response to pesticide exposure in vitro. 
  • Decoding individual finger movements from one hand using human EEG signals. 
  • Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window. 
  • Determinants of a subject's decision to participate in clinical anesthesia research. 
  • Deterministic and stochastic features of fMRI data: implications for analysis of event-related experiments. 
  • Development and validation of the Singing Voice Handicap-10. 
  • Development of Concise Physical Performance Test Batteries in Young Athletes. 
  • Diet and dental topography in pitheciine seed predators. 
  • Dietary Patterns and Cognitive Decline Among Chinese Older Adults. 
  • Dietary patterns differ between urban and rural older, long-term survivors of breast, prostate, and colorectal cancer and are associated with body mass index. 
  • Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis. 
  • Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. 
  • Differentiation and classification of RNA motifs using small molecule-based pattern recognition. 
  • Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. 
  • Discriminating multiple motor imageries of human hands using EEG. 
  • Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. 
  • Distribution and diversity of planktonic fungi in the West Pacific Warm Pool. 
  • Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. 
  • Effects of temperature acclimation on Pacific bluefin tuna (Thunnus orientalis) cardiac transcriptome. 
  • Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. 
  • Eight critical skill sets required for manual therapy competency: a Delphi study and factor analysis of physical therapy educators of manual therapy. 
  • Environmental and anthropogenic controls over bacterial communities in wetland soils. 
  • Epitope mapping of the U1 small nuclear ribonucleoprotein particle in patients with systemic lupus erythematosus and mixed connective tissue disease. 
  • Estimating 4D-CBCT from prior information and extremely limited angle projections using structural PCA and weighted free-form deformation for lung radiotherapy. 
  • Ethnic variation in the impact of metabolic syndrome components and chronic kidney disease. 
  • Evaluation of EEG features in decoding individual finger movements from one hand. 
  • Evaluation of the Healthy Eating Index-2005. 
  • Evidence for a grooming claw in a North American adapiform primate: implications for anthropoid origins. 
  • Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. 
  • Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responses. 
  • Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensembles. 
  • Feature-based representations of emotional facial expressions in the human amygdala. 
  • Functional morphology of the Neandertal scapular glenoid fossa. 
  • Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. 
  • Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes. 
  • Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. 
  • Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation. 
  • Genetic structure and genealogy in the Sphagnum subsecundum complex (Sphagnaceae: Bryophyta). 
  • Genetics of incipient speciation in Drosophila mojavensis: II. Host plants and mating status influence cuticular hydrocarbon QTL expression and G x E interactions. 
  • Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. 
  • Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. 
  • Genomics of varicose veins and chronic venous insufficiency. 
  • Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy. 
  • Global climate evolution during the last deglaciation 
  • Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma. 
  • Hands of early primates. 
  • Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. 
  • Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome. 
  • High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. 
  • High spatial resolution proteomic comparison of the brain in humans and chimpanzees. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • Historical effects on beta diversity and community assembly in Amazonian trees. 
  • Host physiological phenotype explains pathogen reservoir potential. 
  • Hostility, anger, and depression predict increases in C3 over a 10-year period. 
  • How specific are negative symptoms and cognitive impairment in schizophrenia? An analysis of PANSS and SCoRS. 
  • Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics. 
  • Identification of quantitative trait loci and a candidate locus for freezing tolerance in controlled and outdoor environments in the overwintering crucifer Boechera stricta. 
  • Idiosyncratic responding during movie-watching predicted by age differences in attentional control. 
  • Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. 
  • Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. 
  • Initial characterization of micafungin pulmonary delivery via two different nebulizers and multivariate data analysis of aerosol mass distribution profiles. 
  • Isolation and minimization of head motion-induced signal variations in fMRI data using independent component analysis. 
  • Kernel Principal Component analysis through time for voice disorder classification. 
  • Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. 
  • Latent class analysis is useful to classify pregnant women into dietary patterns. 
  • Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis. 
  • Lower molar shape and size in prosimian and platyrrhine primates. 
  • Macroecological patterns of genetic structure and diversity in the aquatic moss Platyhypnidium riparioides. 
  • Mapping human genetic diversity in Asia. 
  • Mechanisms of action selection and timing in substantia nigra neurons. 
  • Metabolic profiles predict adverse events after coronary artery bypass grafting. 
  • Metabolomic mapping of atypical antipsychotic effects in schizophrenia. 
  • Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. 
  • Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. 
  • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. 
  • Motivation and satisfaction among community health workers administering rapid diagnostic tests for malaria in Western Kenya. 
  • Near-absent levels of segregational variation suggest limited opportunities for the introduction of genetic variation via homeologous chromosome pairing in synthetic neoallotetraploid Mimulus. 
  • Neuronal assembly detection and cell membership specification by principal component analysis. 
  • Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention. 
  • Novel loci and pathways significantly associated with longevity. 
  • One haploid parent contributes 100% of the gene pool for a widespread species in northwest North America. 
  • Performance monitoring and cognitive control in individuals with mild traumatic brain injury. 
  • Peripheral blood metabolite profiles associated with new onset atrial fibrillation. 
  • Persistent infection with neurotropic herpes viruses and cognitive impairment. 
  • Physiology of neuronal subtypes in the respiratory-vocal integration nucleus retroamigualis of the male zebra finch. 
  • Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data. 
  • Predicting real-time 3D deformation field maps (DFM) based on volumetric cine MRI (VC-MRI) and artificial neural networks for on-board 4D target tracking: a feasibility study. 
  • Predictors of postpartum weight change among overweight and obese women: results from the Active Mothers Postpartum study. 
  • Prioritizing culture change in nursing homes: perspectives of residents, staff, and family members. 
  • Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking. 
  • Psychometric examination of the Persian version of Osteoarthritis Knee and Hip Quality of Life questionnaire. 
  • Quality of reporting on randomised controlled trials of auriculotherapy for pain. 
  • Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. 
  • RNA Pol II accumulates at promoters of growth genes during developmental arrest. 
  • RNA-seq: impact of RNA degradation on transcript quantification. 
  • Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. 
  • Radiomics analysis using stability selection supervised component analysis for right-censored survival data. 
  • Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. 
  • Reduction of echo decorrelation via complex principal component filtering. 
  • Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. 
  • Replication analysis for composition of the Delirium Motor Subtype Scale (DMSS) in a referral cohort from Northern India. 
  • Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression. 
  • Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. 
  • Self-perceived burden in cancer patients: validation of the Self-perceived Burden Scale. 
  • Serum proteomic analysis focused on fibrosis in patients with hepatitis C virus infection. 
  • Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis. 
  • Sex, temperament, and family context: how the interaction of early factors differentially predict adolescent alcohol use and are mediated by proximal adolescent factors. 
  • Shape "break-and-repair" strategy and its application to automated medical image segmentation. 
  • Simultaneous object classification and segmentation with high-order multiple shape models. 
  • Simultaneous top-down modulation of the primary somatosensory cortex and thalamic nuclei during active tactile discrimination. 
  • Smelling wrong: Hormonal contraception in lemurs alters critical female odour cues. 
  • Socioeconomic status and obesity in Cairo, Egypt: a heavy burden for all. 
  • Spatial properties and functional organization of small bistratified ganglion cells in primate retina. 
  • Speciation on a local geographic scale: the evolution of a rare rock outcrop specialist in Mimulus. 
  • Statistical challenges in preprocessing in microarray experiments in cancer. 
  • Strong Selection at MHC in Mexicans since Admixture. 
  • Temporal Patterns in Sheep Fetal Heart Rate Variability Correlate to Systemic Cytokine Inflammatory Response: A Methodological Exploration of Monitoring Potential Using Complex Signals Bioinformatics. 
  • Tensor network factorizations: Relationships between brain structural connectomes and traits. 
  • The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. 
  • The Vindija Neanderthal scapular glenoid fossa: comparative shape analysis suggests evo-devo changes among Neanderthals. 
  • The diagnostic criteria and structure of catatonia. 
  • The genomic relationship between primary breast carcinomas and their nodal metastases. 
  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. 
  • The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. 
  • The upper limb of Australopithecus sediba. 
  • Tissue-specific genetic control of splicing: implications for the study of complex traits. 
  • Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure. 
  • Transcript expression in endometrial cancers from Black and White patients. 
  • Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. 
  • Transcriptome analysis of mouse stem cells and early embryos. 
  • Unified approaches to assessing treatment effect of traditional Chinese medicine based on health profiles. 
  • Unlearning chronic pain: A randomized controlled trial to investigate changes in intrinsic brain connectivity following Cognitive Behavioral Therapy. 
  • Use of 16S ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia. 
  • Validation of a short version of the glaucoma medication self-efficacy questionnaire. 
  • Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization. 
  • Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. 
  • Variation and fitness costs for tolerance to different types of herbivore damage in Boechera stricta genotypes with contrasting glucosinolate structures. 
  • Whole-brain activity mapping onto a zebrafish brain atlas. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Grambow, Steven C., Assistant Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, School of Nursing
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering