Feedback, Physiological
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Subject Areas on Research
- A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.
- A circuit for motor cortical modulation of auditory cortical activity.
- A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
- A feedback loop in the polo-like kinase activation pathway.
- A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions.
- A noisy linear map underlies oscillations in cell size and gene expression in bacteria.
- A role for MAPK in feedback inhibition of Tcrb recombination.
- A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.
- A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea.
- Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
- Action, time and the basal ganglia.
- Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche.
- Allele-specific regulation of TCR beta variable gene segment chromatin structure.
- Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
- An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants.
- Analysis of Homeostatic Mechanisms in Biochemical Networks.
- Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches.
- Aven-dependent activation of ATM following DNA damage.
- Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.
- Bioelectronic measurement and feedback control of molecules in living cells.
- CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction.
- Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
- Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
- Cell biology. Enforcing the Greatwall in mitosis.
- Cellular senescence mediated by p16INK4A-coupled miRNA pathways.
- CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.
- Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.
- Decoding biological principles using gene circuits.
- Developmental renin expression in mice with a defective renin-angiotensin system.
- Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
- Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats.
- Elements of biological oscillations in time and space.
- Emergent bistability by a growth-modulating positive feedback circuit.
- Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.
- Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.
- Feedback control of T-cell receptor activation.
- Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo.
- Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.
- Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.
- Feedback-mediated dynamics in a model of a compliant thick ascending limb.
- Feedback-mediated dynamics in a model of coupled nephrons with compliant thick ascending limbs.
- Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.
- Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation.
- Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis.
- Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.
- Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
- Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
- Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants.
- How the brainstem controls orofacial behaviors comprised of rhythmic actions.
- Hypertonic hyperglycemia progresses to diabetes faster than normotonic hyperglycemia.
- IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
- Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
- Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.
- Intact negative feedback of four cardiac hormones in congestive heart failure.
- Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age.
- Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
- Long-term monitoring of bacteria undergoing programmed population control in a microchemostat.
- Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
- Measurement of evoked potentials during thalamic deep brain stimulation.
- Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
- Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics.
- Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway.
- Modeling the effects of positive and negative feedback in kidney blood flow control.
- Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.
- Negative feedback enhances robustness in the yeast polarity establishment circuit.
- Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.
- New light on an age-old issue.
- Noise propagation in gene regulation networks involving interlinked positive and negative feedback loops.
- Noise reduction by diffusional dissipation in a minimal quorum sensing motif.
- Origin of bistability underlying mammalian cell cycle entry.
- Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.
- Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback.
- Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans.
- Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans.
- Positive feedback of G1 cyclins ensures coherent cell cycle entry.
- Post-translational modifications regulate the ticking of the circadian clock.
- Post-translational regulation enables robust p53 regulation.
- Processing Oscillatory Signals by Incoherent Feedforward Loops.
- Quantifying negative feedback regulation by micro-RNAs.
- Recurrent cortical circuits implement concentration-invariant odor coding.
- Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
- Regulation of lymphocyte development and activation by the LAT family of adapter proteins.
- Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.
- Reliability of transcriptional cycles and the yeast cell-cycle oscillator.
- Reversible protein phosphorylation regulates circadian rhythms.
- Role of competition between polarity sites in establishing a unique front.
- SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a.
- Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus.
- Signal duration and the time scale dependence of signal integration in biochemical pathways.
- Singularity in polarization: rewiring yeast cells to make two buds.
- Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations.
- Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism.
- Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.
- TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
- The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
- The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
- The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
- Transport efficiency and workload distribution in a mathematical model of the thick ascending limb.
- Tubuloglomerular feedback signal transduction in a short loop of henle.
- Turning T-cell receptor beta recombination on and off: more questions than answers.
- Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.
- Urethral flow-responsive afferents in the cat sacral dorsal root ganglia.
- cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.
- miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.
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Keywords of People
- Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
- Lew, Daniel Julio, James B. Duke Professor of Pharmacology and Cancer Biology, Cell Biology