Feedback, Physiological

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  Subject Areas on Research

  • A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. 
  • A circuit for motor cortical modulation of auditory cortical activity. 
  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A feedback loop in the polo-like kinase activation pathway. 
  • A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions. 
  • A noisy linear map underlies oscillations in cell size and gene expression in bacteria. 
  • A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. 
  • A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea. 
  • Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. 
  • Action, time and the basal ganglia. 
  • Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche. 
  • Allele-specific regulation of TCR beta variable gene segment chromatin structure. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. 
  • Analysis of Homeostatic Mechanisms in Biochemical Networks. 
  • Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches. 
  • Aven-dependent activation of ATM following DNA damage. 
  • Beyond symmetry-breaking: competition and negative feedback in GTPase regulation. 
  • Bioelectronic measurement and feedback control of molecules in living cells. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. 
  • Cell biology. Enforcing the Greatwall in mitosis. 
  • Cell-cycle control of cell polarity in yeast. 
  • Cellular senescence mediated by p16INK4A-coupled miRNA pathways. 
  • CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. 
  • Complexity of the autonomic heart rate control in coronary artery occlusion in patients with and without prior myocardial infarction. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Decoding biological principles using gene circuits. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. 
  • Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion. 
  • E2F1: a magic bullet for atherosclerosis? 
  • Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats. 
  • Elements of biological oscillations in time and space. 
  • Emergent bistability by a growth-modulating positive feedback circuit. 
  • Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Feedback control of T-cell receptor activation. 
  • Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. 
  • Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins. 
  • Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. 
  • Feedback-mediated dynamics in a model of a compliant thick ascending limb. 
  • Feedback-mediated dynamics in a model of coupled nephrons with compliant thick ascending limbs. 
  • Feedback-tracking microrheology in living cells. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation. 
  • Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. 
  • Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. 
  • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. 
  • Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • How the brainstem controls orofacial behaviors comprised of rhythmic actions. 
  • Hypertonic hyperglycemia progresses to diabetes faster than normotonic hyperglycemia. 
  • IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. 
  • Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. 
  • Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit. 
  • Intact negative feedback of four cardiac hormones in congestive heart failure. 
  • Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age. 
  • Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. 
  • Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. 
  • Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. 
  • Measurement of evoked potentials during thalamic deep brain stimulation. 
  • Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. 
  • MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92. 
  • Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics. 
  • Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway. 
  • Modeling the effects of positive and negative feedback in kidney blood flow control. 
  • Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. 
  • Negative feedback enhances robustness in the yeast polarity establishment circuit. 
  • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. 
  • New light on an age-old issue. 
  • Noise propagation in gene regulation networks involving interlinked positive and negative feedback loops. 
  • Noise reduction by diffusional dissipation in a minimal quorum sensing motif. 
  • Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina. 
  • Origin of bistability underlying mammalian cell cycle entry. 
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. 
  • Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback. 
  • Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. 
  • Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans. 
  • Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility. 
  • Positive feedback of G1 cyclins ensures coherent cell cycle entry. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Post-translational regulation enables robust p53 regulation. 
  • Processing Oscillatory Signals by Incoherent Feedforward Loops. 
  • Quantifying negative feedback regulation by micro-RNAs. 
  • Recurrent cortical circuits implement concentration-invariant odor coding. 
  • Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. 
  • Regulation of lymphocyte development and activation by the LAT family of adapter proteins. 
  • Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny. 
  • Reliability of transcriptional cycles and the yeast cell-cycle oscillator. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Role of competition between polarity sites in establishing a unique front. 
  • SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. 
  • Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus. 
  • Signal duration and the time scale dependence of signal integration in biochemical pathways. 
  • Singularity in polarization: rewiring yeast cells to make two buds. 
  • Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations. 
  • Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism. 
  • Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. 
  • The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. 
  • The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. 
  • The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. 
  • Transport efficiency and workload distribution in a mathematical model of the thick ascending limb. 
  • Tubuloglomerular feedback signal transduction in a short loop of henle. 
  • Turning T-cell receptor beta recombination on and off: more questions than answers. 
  • Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. 
  • Urethral flow-responsive afferents in the cat sacral dorsal root ganglia. 
  • WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. 
  • cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia. 
  • miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. 
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  Keywords of People

  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology