Tumor Suppressor Proteins

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  Subject Areas on Research

  • A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. 
  • A de novo frame-shift mutation in the tuberin gene. 
  • A decrease in the dose of the lgl tumor suppressor increases life span of Drosophila in stress and is related to the maternal effect. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. 
  • A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. 
  • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck. 
  • A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. 
  • A novel splice site mutation (156 + 1G-->A) in the TSC2 gene. 
  • A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study. 
  • A randomized phase II trial of veliparib, radiotherapy, and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study. 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ATM activation in normal human tissues and testicular cancer. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. 
  • ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM--a key determinant of multiple cellular responses to irradiation. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. 
  • Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An expanded role of the tumor suppressor TSC1 in T cell tolerance. 
  • An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. 
  • Analysis of the gene coding for the BRCA2-interacting protein PALB2 in hereditary prostate cancer. 
  • Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer. 
  • Assessment of autoantibodies to meningioma in a population-based study. 
  • Association and interactions between DNA repair gene polymorphisms and adult glioma. 
  • Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study. 
  • Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma. 
  • Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. 
  • Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Aven-dependent activation of ATM following DNA damage. 
  • Axon guidance pathways served as common targets for human speech/language evolution and related disorders. 
  • BAP1 Tumor Predisposition Syndrome Presenting as a Recurrent Ovarian Sex Cord-Stromal Tumor. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • Bevacizumab for patients with metastatic renal cancer: an update. 
  • Bmp and Fgf signaling are essential for liver specification in zebrafish. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone. 
  • Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. 
  • Cell biology: A BID for the pathway. 
  • Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. 
  • Cell cycle. Checking two steps. 
  • Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. 
  • Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia. 
  • Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. 
  • Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. 
  • Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Cilengitide with metronomic temozolomide, procarbazine, and standard radiotherapy in patients with glioblastoma and unmethylated MGMT gene promoter in ExCentric, an open-label phase II trial. 
  • Combined effects of the p53 and p73 polymorphisms on lung cancer risk. 
  • Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. 
  • Combined p53-related genetic variants together with HPV infection increase oral cancer risk. 
  • Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. 
  • Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis. 
  • Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying). 
  • Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center. 
  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 
  • Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene. 
  • Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions. 
  • Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. 
  • Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. 
  • Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. 
  • Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. 
  • Development of the human female reproductive tract. 
  • Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. 
  • Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • EURACAN/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach. 
  • Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial. 
  • Endosome and INPP4B. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. 
  • Estrogen treatment enhances hereditary renal tumor development in Eker rats. 
  • Everolimus tablets for patients with subependymal giant cell astrocytoma. 
  • Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. 
  • Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. 
  • Expression and assay of recombinant ATM. 
  • Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome. 
  • Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. 
  • Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. 
  • Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. 
  • Functional assessment of variants in the TSC1 and TSC2 genes identified in individuals with Tuberous Sclerosis Complex. 
  • Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene markers in brain tumors: what the epileptologist should know. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma. 
  • Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. 
  • Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. 
  • Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck. 
  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck. 
  • Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. 
  • Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. 
  • Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 
  • Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. 
  • Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23. 
  • Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis. 
  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. 
  • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. 
  • Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. 
  • HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair. 
  • Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. 
  • Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. 
  • Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. 
  • Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. 
  • Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. 
  • Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. 
  • Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein. 
  • Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF). 
  • Identification of cis-suppression of human disease mutations by comparative genomics. 
  • Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. 
  • Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. 
  • Immunohistochemical localization of netrin-1 in the embryonic chick nervous system. 
  • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. 
  • In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. 
  • Influence of ATM function on telomere metabolism. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Initial testing (stage 1) of temozolomide by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. 
  • Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. 
  • Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. 
  • Integrative Molecular Characterization of Malignant Pleural Mesothelioma. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice. 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. 
  • Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. 
  • LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer. 
  • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. 
  • Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection. 
  • Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma. 
  • Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling. 
  • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. 
  • Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. 
  • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • MGMT immunoexpression in silent subtype 3 pituitary adenomas: possible therapeutic implications. 
  • MGMT immunoexpression predicts responsiveness of pituitary tumors to temozolomide therapy. 
  • MGMT: Immunohistochemical Detection in High-Grade Astrocytomas. 
  • Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. 
  • Malignant Mesothelioma and Its Non-Asbestos Causes. 
  • Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms. 
  • Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. 
  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains. 
  • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. 
  • Mechanisms of action of rapamycin in gliomas. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. 
  • Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. 
  • Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. 
  • Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Molecular Analysis of a Patient With Neurofibromatosis 2 (NF2) and Peritoneal Malignant Mesothelioma. 
  • Molecular alternations in uveal melanoma. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. 
  • Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. 
  • Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. 
  • Molecular pathogenesis of malignant gliomas. 
  • Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. 
  • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. 
  • Multiple Genetically Distinct Uveal Melanomas Arise in the Same Eye of Two Patients with Melanosis Oculi. 
  • Multiple signaling pathways involving ATM. 
  • Muscle atrophy in transgenic mice expressing a human TSC1 transgene. 
  • Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen. 
  • Mutation analysis of the TSC2 gene in an African-American family. 
  • Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene. 
  • Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. 
  • Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers. 
  • Mutational analysis of the PTEN gene in human uterine sarcomas. 
  • Netrin-1 and peripheral nerve regeneration in the adult rat. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. 
  • O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors. 
  • Our cells get stressed too! Implications for human disease. 
  • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. 
  • PI3K/Akt and apoptosis: size matters. 
  • PIN1, the cell cycle and cancer. 
  • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. 
  • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. 
  • PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. 
  • PTEN polymorphism (IVS4) is not associated with risk of prostate cancer. 
  • Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells. 
  • Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Pathogenic Germline Variants in 10,389 Adult Cancers. 
  • Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling. 
  • Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. 
  • Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Pills of PTEN? In and out for tumor suppression. 
  • Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. 
  • Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer. 
  • Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease. 
  • Positive selection in noncoding genomic regions of vocal learning birds is associated with genes implicated in vocal learning and speech functions in humans. 
  • Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials. 
  • Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. 
  • Protein patterns and proteins that identify subtypes of glioblastoma multiforme. 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. 
  • RASSF4 is required for skeletal muscle differentiation. 
  • Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers. 
  • Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. 
  • Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. 
  • Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. 
  • Receptor signaling in immune cell development and function. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. 
  • Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. 
  • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. 
  • SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. 
  • STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. 
  • Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. 
  • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. 
  • Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase. 
  • Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. 
  • Substrate specificities and identification of putative substrates of ATM kinase family members. 
  • Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. 
  • Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • Systemic inflammatory response syndrome after human syngeneic intestinal transplantation: evidence for disruption of enterocyte barrier function. 
  • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. 
  • Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • Tetraspanin CD37 protects against the development of B cell lymphoma. 
  • The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. 
  • The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. 
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. 
  • The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. 
  • The Genetic Basis of Hepatosplenic T-cell Lymphoma. 
  • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis. 
  • The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group. 
  • The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. 
  • The functions and regulation of the PTEN tumour suppressor: new modes and prospects. 
  • The genomic landscape of familial glioma. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The many substrates and functions of ATM. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. 
  • The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. 
  • The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. 
  • The von Hippel-Lindau tumor suppressor gene and kidney cancer. 
  • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. 
  • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. 
  • Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. 
  • Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. 
  • Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Twenty-year survival in glioblastoma: a case report and molecular profile. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Tyrosine kinase inhibitors in renal cell carcinoma. 
  • Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. 
  • [Cowden disease]. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
  • p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53: a two-faced cancer gene. 
  • p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function. 
  • p63 expression profile in normal and malignant prostate epithelial cells. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature. 
  • p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers. 
  • p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. 
  • p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Chen, Ming, Associate Professor in Pathology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology